SCHEMBL9915577

SCHEMBL9915577

[C-]#[N+]/C(C#N)=C1\C(=C)Cc2ccccc21

nearest known ligand 0.32

Predicted protein targets (top 6)

geneUniProtsupporting neighboursconfidence
RNASEH1 O60930 1/20 0.32
HTT P42858 1/20 0.31
MAOA P21397 1/20 0.31
GAA P10253 2/20 0.30
PKM P14618 1/20 0.30
TLR9 Q9NR96 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL9915582 0.84 MEN1 (0.30)
SCHEMBL9915584 0.77
SCHEMBL10062478 0.75 S100A4 (0.32)
SCHEMBL10018093 0.72
SCHEMBL9970447 0.72
SCHEMBL9915569 0.71 TDP2 (0.36) HTTMAOA
SCHEMBL9970451 0.70 CES1 (0.37) MAOAGAA
SCHEMBL31571396 0.70 CES1 (0.37) MAOAGAA
SCHEMBL9881029 0.70 CES1 (0.37) MAOAGAA
SCHEMBL12887845 0.69 KDM4E (0.35) MAOA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-8197722-B2 Irradiating the compound (containing two electron donor groups and a bridge of pi-conjugated bonds containing electron donor groups) with light, and the compound is converted to a multi-photon electronically excited state THE CALIFORNIA INSTITUTE OF TECHNOLOGY (US) 2012-06-12 US disclosed
US-20080283804-A1 include a bridge of pi-conjugated bonds connecting electron donating or accepting groups; electronically excited upon absorption lead to formation of Lewis acidic species, Lewis basic species, radical species or ionic species; chromogens use in engineering, biological, and medicinal field CALIFORNIA INSTITUTE OF TECHNOLOGY 2008-11-20 US disclosed