Predicted protein targets (top 1)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DHFR | P00374 | 9/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9916086 | 1.00 | DHFR (0.54) | DHFR | |
| SCHEMBL6974948 | 0.94 | DHFR (0.53) | DHFR | |
| SCHEMBL1128102 | 0.94 | DHFR (0.53) | DHFR | |
| SCHEMBL1128106 | 0.93 | DHFR (0.53) | DHFR | |
| Ch-1504 L-Isomer SCHEMBL29430181 | 0.91 | DHFR (0.65) | DHFR | |
| Ch-1504 L-Isomer SCHEMBL1052620 | 0.91 | DHFR (0.65) | DHFR | |
| Ch-1504 SCHEMBL7281 | 0.91 | DHFR (0.65) | DHFR | |
| Ch-1504 SCHEMBL29430185 | 0.91 | DHFR (0.65) | DHFR | |
| SCHEMBL6974971 | 0.87 | DHFR (0.56) | DHFR | |
| SCHEMBL6978957 | 0.87 | DHFR (0.56) | DHFR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012078708-A1 | COMBINATION COMPRISING METHOTREXATE AND AN ANTIFOLATE COMPOUND | CHELSEA THERAPEUTICS, INC. (US) | 2012-06-14 | — | — | WO | disclosed |
| WO-2009126637-A1 | ANTIFOLATE COMPOSITIONS | CHELSEA THERAPEUTICS, INC. (US) | 2009-10-15 | — | — | WO | disclosed |
| WO-2009126639-A1 | CRYSTALLINE SALT FORMS OF ANTIFOLATE COMPOUNDS AND METHODS OF MANUFACTURING THEREOF | CHELSEA THERAPEUTICS, INC. (US) | 2009-10-15 | — | — | WO | disclosed |