Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GAA | P10253 | 2/20 | 0.42 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.42 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.42 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.42 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.42 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.42 |
| ▸ | CYP19A1 | P11511 | 4/20 | 0.42 |
| ▸ | MAPT | P10636 | 4/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.41 |
| ▸ | TP53 | P04637 | 1/20 | 0.40 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.40 |
| ▸ | NPC1 | O15118 | 2/20 | 0.40 |
| ▸ | RAB9A | P51151 | 2/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 2/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.39 |
| ▸ | ELANE | P08246 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9918731 | 0.90 | NPC1 (0.41) | GAACYP1A2CYP3A4CYP2C9CYP2C19 | |
| SCHEMBL127772 | 0.73 | TSHR (0.43) | CYP3A4MAPTSMN1; SMN2ALDH1A1MAPK1 | |
| SCHEMBL130676 | 0.73 | TSHR (0.43) | CYP1A2CYP2C19SMN1; SMN2ALDH1A1MAPK1 | |
| SCHEMBL9918732 | 0.72 | ALDH1A1 (0.47) | GAACYP1A2CYP3A4CYP2C9CYP2C19 | |
| SCHEMBL5356970 | 0.71 | NPC1 (0.48) | NPSR1CYP19A1SMN1; SMN2ALDH1A1MAPK1 | |
| SCHEMBL12832721 | 0.70 | TSHR (0.42) | CYP3A4MAPTSMN1; SMN2ALDH1A1MAPK1 | |
| SCHEMBL9918734 | 0.68 | TSHR (0.43) | GAACYP3A4MAPTSMN1; SMN2ALDH1A1 | |
| SCHEMBL13243606 | 0.68 | NOTUM (0.40) | SMN1; SMN2ALDH1A1KMT2AMEN1HTT | |
| SCHEMBL22272841 | 0.66 | RAB9A (0.49) | NPSR1CYP19A1MAPTSMN1; SMN2ALDH1A1 | |
| SCHEMBL15932081 | 0.66 | KMT2A (0.46) | GAACYP19A1MAPTSMN1; SMN2ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20120149662-A1 | Heterocyclic Compounds as Janus Kinase Inhibitors | BIOCRYST PHARMACEUTICALS, INC. (US) | 2012-06-14 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120149662-A1 | Heterocyclic Compounds as Janus Kinase Inhibitors | JAK2, JAK1, JAK3 | GAA 3039/4885CYP1A2 1299/4885CYP3A4 1570/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.