Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 11/20 | 0.67 |
| ▸ | MEN1 | O00255 | 9/20 | 0.66 |
| ▸ | KMT2A | Q03164 | 9/20 | 0.66 |
| ▸ | HSD17B10 | Q99714 | 6/20 | 0.66 |
| ▸ | MAPT | P10636 | 6/20 | 0.66 |
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.66 |
| ▸ | ALOX15 | P16050 | 4/20 | 0.66 |
| ▸ | BRCA1 | P38398 | 3/20 | 0.66 |
| ▸ | HBB | P68871 | 2/20 | 0.66 |
| ▸ | RXFP1 | Q9HBX9 | 2/20 | 0.66 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.66 |
| ▸ | TP53 | P04637 | 1/20 | 0.66 |
| ▸ | HPGD | P15428 | 6/20 | 0.58 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.54 |
| ▸ | LMNA | P02545 | 2/20 | 0.52 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.52 |
| ▸ | RECQL | P46063 | 1/20 | 0.51 |
| ▸ | GAA | P10253 | 3/20 | 0.49 |
| ▸ | HTT | P42858 | 2/20 | 0.49 |
| ▸ | MPO | P05164 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15572874 | 0.77 | MEN1 (0.68) | ALDH1A1MEN1KMT2AHSD17B10MAPT | |
| SCHEMBL4426903 | 0.75 | ALDH1A1 (0.56) | ALDH1A1MEN1KMT2AHSD17B10MAPT | |
| SCHEMBL4331808 | 0.70 | ALDH1A1 (0.65) | ALDH1A1MEN1KMT2AHSD17B10MAPT | |
| SCHEMBL28313771 | 0.69 | CYP3A4 (0.46) | ALDH1A1MEN1KMT2AMAPTKDM4E | |
| SCHEMBL30360992 | 0.68 | CYP3A4 (0.59) | ALDH1A1MEN1KMT2AMAPTKDM4E | |
| SCHEMBL834711 | 0.67 | EEF2K (0.67) | ALDH1A1MEN1KMT2AHSD17B10MAPT | |
| Ammonia Solution, Strong SCHEMBL9291323 | 0.66 | ALDH1A1 (0.49) | ALDH1A1MEN1KMT2AMAPTKDM4E | |
| SCHEMBL1608900 | 0.66 | AR (0.69) | ALDH1A1KDM4EGAAPOLB | |
| SCHEMBL25705924 | 0.65 | MEN1 (0.59) | ALDH1A1MEN1KMT2AKDM4EHPGD | |
| Water SCHEMBL28213911 | 0.65 | ALDH1A1 (0.91) | ALDH1A1MEN1KMT2AHSD17B10MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20120149673-A1 | INHIBITORS OF STORE OPERATED CALCIUM RELEASE | CALCIMEDICA, INC. (US) | 2012-06-14 | — | — | US | disclosed |
| US-20120149673-A1 | INHIBITORS OF STORE OPERATED CALCIUM RELEASE | CALCIMEDICA, INC. (US) | 2012-06-14 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120149673-A1 | INHIBITORS OF STORE OPERATED CALCIUM RELEASE | ORAI1, SARAF, RYR2 | ALDH1A1 4125/4885MEN1 3485/4885KMT2A 4780/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.