Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MCL1 | Q07820 | 1/20 | 0.58 |
| ▸ | DGAT1 | O75907 | 3/20 | 0.51 |
| ▸ | MAPT | P10636 | 1/20 | 0.45 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.45 |
| ▸ | HTT | P42858 | 1/20 | 0.45 |
| ▸ | HBB | P68871 | 1/20 | 0.45 |
| ▸ | NPC1 | O15118 | 2/20 | 0.44 |
| ▸ | RAB9A | P51151 | 2/20 | 0.44 |
| ▸ | SRD5A2 | P31213 | 1/20 | 0.44 |
| ▸ | DAO | P14920 | 1/20 | 0.44 |
| ▸ | TSHR | P16473 | 1/20 | 0.44 |
| ▸ | NAPRT | Q6XQN6 | 1/20 | 0.44 |
| ▸ | CES2 | O00748 | 1/20 | 0.44 |
| ▸ | CES1 | P23141 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.44 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.44 |
| ▸ | GLS | O94925 | 1/20 | 0.43 |
| ▸ | KMO | O15229 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6405466 | 0.94 | DGAT1 (0.59) | MCL1DGAT1MAPTRAB9AALDH1A1 | |
| SCHEMBL3316742 | 0.94 | DGAT1 (0.59) | MCL1DGAT1MAPTRAB9AALDH1A1 | |
| SCHEMBL20370264 | 0.94 | DGAT1 (0.59) | MCL1DGAT1MAPTRAB9AALDH1A1 | |
| SCHEMBL28814606 | 0.94 | MCL1 (0.58) | MCL1DGAT1MAPTALOX15HTT | |
| SCHEMBL6399371 | 0.94 | DGAT1 (0.59) | MCL1DGAT1MAPTRAB9AALDH1A1 | |
| SCHEMBL6405464 | 0.94 | DGAT1 (0.59) | MCL1DGAT1MAPTRAB9AALDH1A1 | |
| SCHEMBL6399369 | 0.94 | DGAT1 (0.59) | MCL1DGAT1MAPTRAB9AALDH1A1 | |
| SCHEMBL22570568 | 0.91 | MCL1 (0.52) | MCL1DGAT1MAPTALOX15HTT | |
| SCHEMBL8351873 | 0.90 | MCL1 (0.50) | MCL1DGAT1MAPTALOX15HTT | |
| SCHEMBL5918565 | 0.90 | MCL1 (0.50) | MCL1DGAT1MAPTALOX15HTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20120149691-A1 | Pyrrolo [1,2-b] Pyridazine Derivatives as Janus Kinase Inhibitors | BIOCRYST PHARMACEUTICALS, INC. (US) | 2012-06-14 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120149691-A1 | Pyrrolo [1,2-b] Pyridazine Derivatives as Janus Kinase Inhibitors | JAK1, JAK2, JAK3 | MCL1 58/4885DGAT1 4438/4885MAPT 4022/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.