Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 4/20 | 0.64 |
| ▸ | CNR1 | P21554 | 5/20 | 0.56 |
| ▸ | CNR2 | P34972 | 2/20 | 0.56 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.56 |
| ▸ | IGF1R | P08069 | 1/20 | 0.54 |
| ▸ | NPC1 | O15118 | 1/20 | 0.54 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.54 |
| ▸ | GAA | P10253 | 1/20 | 0.54 |
| ▸ | MAPT | P10636 | 1/20 | 0.54 |
| ▸ | RAB9A | P51151 | 1/20 | 0.54 |
| ▸ | HTT | P42858 | 1/20 | 0.54 |
| ▸ | USP10 | Q14694 | 1/20 | 0.53 |
| ▸ | PIK3C3 | Q8NEB9 | 1/20 | 0.53 |
| ▸ | USP13 | Q92995 | 1/20 | 0.53 |
| ▸ | ALK | Q9UM73 | 1/20 | 0.53 |
| ▸ | LMNA | P02545 | 1/20 | 0.53 |
| ▸ | KDR | P35968 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13191864 | 0.93 | EGFR (0.61) | EGFRCNR1CNR2MAPK1NPC1 | |
| SCHEMBL18231973 | 0.88 | HTT (0.72) | EGFRCNR1CNR2MAPTHTT | |
| SCHEMBL9921511 | 0.88 | USP10 (0.70) | EGFRCNR1CNR2ALDH1A1MAPT | |
| SCHEMBL9921508 | 0.83 | HTT (0.74) | EGFRCNR1CNR2MAPK1ALDH1A1 | |
| SCHEMBL7473179 | 0.82 | MAPK1 (0.58) | EGFRCNR1CNR2MAPK1MAPT | |
| SCHEMBL7472725 | 0.81 | EGFR (0.61) | EGFRMAPK1HTTUSP10PIK3C3 | |
| SCHEMBL7495957 | 0.81 | MEN1 (0.57) | EGFRCNR1CNR2MAPK1ALDH1A1 | |
| SCHEMBL9921503 | 0.80 | PDE5A (0.69) | ALDH1A1MAPT | |
| SCHEMBL11846542 | 0.79 | EGFR (0.61) | EGFRMAPK1ALDH1A1GAAMAPT | |
| SCHEMBL9921504 | 0.79 | EGFR (0.67) | EGFRCNR1CNR2MAPK1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20120258975-A1 | Potent Small Molecule Inhibitors of Autophagy, and Methods of Use Thereof | SHANGHAI INSTITUTE OF ORGANIC CHEMISTRY (CN) | 2012-10-11 | — | — | US | disclosed |
| US-20120258975-A1 | Potent Small Molecule Inhibitors of Autophagy, and Methods of Use Thereof | SHANGHAI INSTITUTE OF ORGANIC CHEMISTRY (CN) | 2012-10-11 | — | — | US | disclosed |
| WO-2012079079-A1 | PRODUCTION OF INDUCED PLURIPOTENT STEM CELLS | PRESIDENT AND FELLOWS OF HARVARD COLLEGE (US) | 2012-06-14 | — | — | WO | disclosed |
| WO-2011011522-A2 | POTENT SMALL MOLECULE INHIBITORS OF AUTOPHAGY, AND METHODS OF USE THEREOF | PRESIDENT AND FELLOWS OF HARVARD COLLEGE (US) | 2011-01-27 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120258975-A1 | Potent Small Molecule Inhibitors of Autophagy, and Methods of Use Thereof | ATG7, BECN1, SQSTM1 | EGFR 2099/4885CNR1 3419/4885CNR2 3654/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.