Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 1/20 | 0.58 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.58 |
| ▸ | PAOX | Q6QHF9 | 1/20 | 0.48 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.43 |
| ▸ | CASP2 | P42575 | 1/20 | 0.39 |
| ▸ | RECQL | P46063 | 1/20 | 0.38 |
| ▸ | MMP1 | P03956 | 1/20 | 0.37 |
| ▸ | MMP2 | P08253 | 1/20 | 0.37 |
| ▸ | MMP3 | P08254 | 1/20 | 0.37 |
| ▸ | MMP9 | P14780 | 1/20 | 0.37 |
| ▸ | NAAA | Q02083 | 1/20 | 0.36 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.36 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.36 |
| ▸ | TSHR | P16473 | 1/20 | 0.36 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.36 |
| ▸ | CTSD | P07339 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.35 |
| ▸ | FAAH | O00519 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9921438 | 1.00 | MEN1 (0.58) | MEN1KMT2APAOXMCL1CASP2 | |
| SCHEMBL9921406 | 1.00 | MEN1 (0.58) | MEN1KMT2APAOXMCL1CASP2 | |
| SCHEMBL9921399 | 1.00 | MEN1 (0.58) | MEN1KMT2APAOXMCL1CASP2 | |
| SCHEMBL9921400 | 1.00 | MEN1 (0.58) | MEN1KMT2APAOXMCL1CASP2 | |
| SCHEMBL22053139 | 0.86 | MEN1 (0.67) | MEN1KMT2APAOXMCL1CASP2 | |
| SCHEMBL165731 | 0.85 | — | — | |
| SCHEMBL12799428 | 0.84 | MEN1 (0.78) | MEN1KMT2AMCL1CASP2RECQL | |
| SCHEMBL16384407 | 0.84 | MEN1 (0.56) | MEN1KMT2APAOXRECQLNAAA | |
| SCHEMBL10966458 | 0.84 | MEN1 (0.56) | MEN1KMT2ARECQLNAAAALDH1A1 | |
| SCHEMBL9921437 | 0.84 | CASP2 (0.57) | MEN1KMT2APAOXMCL1CASP2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 14 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2021195465-A1 | TREATMENT OF ACUTE RESPIRATORY DISTRESS SYNDROME AND RELATED CONDITIONS WITH ANTAGONISTS OF E-SELECTIN | MAGNANI JOHN L (US) | 2021-09-30 | — | — | WO | disclosed |
| WO-2020112581-A1 | NOVEL SUBSTITUTED PIPERAZINE AMIDE COMPOUNDS AS INDOLEAMINE 2, 3-DIOXYGENASE (IDO) INHIBITORS | MERCK SHARP & DOHME CORP. (US) | 2020-06-04 | — | — | WO | disclosed |
| US-8921111-B2 | Polymer based polynucleotide transfection agents | INTEZYNE TECHNOLOGIES (US) | 2014-12-30 | — | — | US | disclosed |
| US-20140302607-A1 | POLYMER BASED POLYNUCLEOTIDE TRANSFECTION AGENTS | INTEZYNE TECHNOLOGIES, INC. (US) | 2014-10-09 | — | — | US | disclosed |
| US-20120237565-A1 | PEGYLATED POLYPLEXES CONTAINING TWO OR MORE DIFFERENT POLYMERS FOR POLYNUCLEOTIDE DELIVERY | INTEZYNE TECHNOLOGIES, INCORPORATED (US) | 2012-09-20 | — | — | US | disclosed |
| US-20120148631-A1 | PEGYLATED POLYPLEXES FOR POLYNUCLEOTIDE DELIVERY | INTEZYNE TECHNOLOGIES, INCORPORATED (US) | 2012-06-14 | — | — | US | disclosed |
| WO-2011130577-A1 | CONTROLLED POLYPLEX ASSEMBLY | INTEZYNE TECHNOLOGIES, INCORPORATED (US) | 2011-10-20 | — | — | WO | disclosed |
| US-20110256227-A1 | CONTROLLED POLYPLEX ASSEMBLY | INTEZYNE TECHNOLOGIES, INC. (US) | 2011-10-20 | — | — | US | disclosed |
| US-20110229528-A1 | PEGYLATED POLYPLEXES FOR POLYNUCLEOTIDE DELIVERY | INTEZYNE TECHNOLOGIES, INCORPORATED (US) | 2011-09-22 | — | — | US | disclosed |
| WO-2011113065-A2 | PEGYLATED POLYPLEXES FOR POLYNUCLEOTIDE DELIVERY | INTEZYNE TECHNOLOGIES, INCORPORATED (US) | 2011-09-15 | — | — | WO | disclosed |
| US-7837982-B2 | Imaging agents | EMORY UNIVERSITY (US) | 2010-11-23 | — | — | US | disclosed |
| US-7425318-B2 | Amyloid plaque aggregation inhibitors and diagnostic imaging agents | THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA (US) | 2008-09-16 | — | — | US | disclosed |
| US-20080219922-A1 | Alzheimer's Disease Imaging Agents | EMORY UNIVERSITY | 2008-09-11 | — | — | US | disclosed |
| US-20070082879-A1 | Imaging Agents | EMORY UNIVERSITY (US) | 2007-04-12 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (6 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120148631-A1 | PEGYLATED POLYPLEXES FOR POLYNUCLEOTIDE DELIVERY | PARN, PUF60, PARG | MEN1 3205/4885KMT2A 3658/4885PAOX 634/4885 |
| US-20120237565-A1 | PEGYLATED POLYPLEXES CONTAINING TWO OR MORE DIFFERENT POLYMERS FOR POLYNUCLEOTIDE DELIVERY | PARN, PARG, PUF60 | MEN1 2969/4885KMT2A 3531/4885PAOX 1139/4885 |
| US-20070082879-A1 | Imaging Agents | SLC7A1, SSTR1, SSTR3 | MEN1 91/4885KMT2A 2212/4885PAOX 4031/4885 |
| US-20080219922-A1 | Alzheimer's Disease Imaging Agents | APP, PSEN1, MAPT | MEN1 274/4885KMT2A 3913/4885PAOX 3388/4885 |
| US-20110229528-A1 | PEGYLATED POLYPLEXES FOR POLYNUCLEOTIDE DELIVERY | PARN, PUF60, PARG | MEN1 3205/4885KMT2A 3658/4885PAOX 634/4885 |
| US-20110256227-A1 | CONTROLLED POLYPLEX ASSEMBLY | PARG, PARN, PUF60 | MEN1 1587/4885KMT2A 2343/4885PAOX 1837/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.