Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTT | P42858 | 6/20 | 0.50 |
| ▸ | AURKA | O14965 | 10/20 | 0.46 |
| ▸ | RPS6KB1 | P23443 | 8/20 | 0.46 |
| ▸ | AURKB | Q96GD4 | 6/20 | 0.46 |
| ▸ | EGFR | P00533 | 2/20 | 0.43 |
| ▸ | NTRK1 | P04629 | 2/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | APP | P05067 | 1/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.40 |
| ▸ | PDE2A | O00408 | 1/20 | 0.40 |
| ▸ | PDE5A | O76074 | 1/20 | 0.40 |
| ▸ | NR2F2 | P24468 | 1/20 | 0.40 |
| ▸ | TTBK1 | Q5TCY1 | 1/20 | 0.39 |
| ▸ | TTBK2 | Q6IQ55 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13171175 | 0.85 | HTT (0.52) | HTTEGFRLMNAAPPMAPK1 | |
| SCHEMBL9921377 | 0.82 | HTT (0.74) | HTTAURKAAURKBEGFRNTRK1 | |
| SCHEMBL9921422 | 0.81 | HTT (0.50) | HTTAURKARPS6KB1AURKBEGFR | |
| SCHEMBL8546216 | 0.75 | AURKA (0.55) | HTTAURKARPS6KB1AURKBEGFR | |
| SCHEMBL9921433 | 0.75 | HTT (0.64) | HTTEGFRLMNAAPPMAPK1 | |
| SCHEMBL8541235 | 0.75 | HTT (0.72) | HTTAURKAEGFRLMNAAPP | |
| SCHEMBL9303626 | 0.74 | PLAAT3 (0.48) | HTTAURKARPS6KB1AURKBEGFR | |
| SCHEMBL8546996 | 0.74 | AURKA (0.48) | HTTAURKARPS6KB1AURKBEGFR | |
| SCHEMBL12340671 | 0.73 | AURKA (0.44) | HTTAURKARPS6KB1AURKBEGFR | |
| SCHEMBL8483065 | 0.73 | HTT (0.64) | HTTAURKAAURKBLMNANR2F2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012079079-A1 | PRODUCTION OF INDUCED PLURIPOTENT STEM CELLS | PRESIDENT AND FELLOWS OF HARVARD COLLEGE (US) | 2012-06-14 | — | — | WO | disclosed |
| WO-2011011522-A2 | POTENT SMALL MOLECULE INHIBITORS OF AUTOPHAGY, AND METHODS OF USE THEREOF | PRESIDENT AND FELLOWS OF HARVARD COLLEGE (US) | 2011-01-27 | — | — | WO | disclosed |