Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CASP2 | P42575 | 1/20 | 0.46 |
| ▸ | DNM1 | Q05193 | 2/20 | 0.44 |
| ▸ | CTSD | P07339 | 1/20 | 0.39 |
| ▸ | FAAH | O00519 | 1/20 | 0.39 |
| ▸ | SLC6A5 | Q9Y345 | 2/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | HPGD | P15428 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.37 |
| ▸ | MTNR1A | P48039 | 1/20 | 0.36 |
| ▸ | MTNR1B | P49286 | 1/20 | 0.36 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.36 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.36 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.36 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.36 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | GLA | P06280 | 1/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
| ▸ | NAAA | Q02083 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13033284 | 0.96 | CASP2 (0.48) | CASP2DNM1CTSDFAAHSLC6A5 | |
| SCHEMBL9921397 | 0.88 | KMT2A (0.45) | DNM1KMT2AHPGDALDH1A1KDM4E | |
| SCHEMBL14607021 | 0.87 | CASP2 (0.57) | CASP2DNM1CTSDFAAHHPGD | |
| SCHEMBL13254848 | 0.86 | CASP2 (0.46) | CASP2DNM1CTSDFAAHSLC6A5 | |
| SCHEMBL15184973 | 0.86 | CASP2 (0.46) | CASP2DNM1CTSDFAAHSLC6A5 | |
| SCHEMBL10081612 | 0.86 | CASP2 (0.46) | CASP2DNM1CTSDFAAHSLC6A5 | |
| SCHEMBL9452842 | 0.83 | DNM1 (0.66) | CASP2DNM1FAAHSLC6A5NAAA | |
| SCHEMBL8353089 | 0.83 | DNM1 (0.66) | CASP2DNM1FAAHSLC6A5NAAA | |
| SCHEMBL10099851 | 0.82 | DNM1 (0.42) | CASP2DNM1FAAHSLC6A5KDM4E | |
| SCHEMBL9921462 | 0.82 | PAOX (0.46) | KMT2AHPGDALDH1A1MTNR1AMTNR1B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8921111-B2 | Polymer based polynucleotide transfection agents | INTEZYNE TECHNOLOGIES (US) | 2014-12-30 | — | — | US | disclosed |
| US-20140302607-A1 | POLYMER BASED POLYNUCLEOTIDE TRANSFECTION AGENTS | INTEZYNE TECHNOLOGIES, INC. (US) | 2014-10-09 | — | — | US | disclosed |
| US-20120237565-A1 | PEGYLATED POLYPLEXES CONTAINING TWO OR MORE DIFFERENT POLYMERS FOR POLYNUCLEOTIDE DELIVERY | INTEZYNE TECHNOLOGIES, INCORPORATED (US) | 2012-09-20 | — | — | US | disclosed |
| US-20120148631-A1 | PEGYLATED POLYPLEXES FOR POLYNUCLEOTIDE DELIVERY | INTEZYNE TECHNOLOGIES, INCORPORATED (US) | 2012-06-14 | — | — | US | disclosed |
| WO-2011130577-A1 | CONTROLLED POLYPLEX ASSEMBLY | INTEZYNE TECHNOLOGIES, INCORPORATED (US) | 2011-10-20 | — | — | WO | disclosed |
| US-20110256227-A1 | CONTROLLED POLYPLEX ASSEMBLY | INTEZYNE TECHNOLOGIES, INC. (US) | 2011-10-20 | — | — | US | disclosed |
| US-20110229528-A1 | PEGYLATED POLYPLEXES FOR POLYNUCLEOTIDE DELIVERY | INTEZYNE TECHNOLOGIES, INCORPORATED (US) | 2011-09-22 | — | — | US | disclosed |
| WO-2011113065-A2 | PEGYLATED POLYPLEXES FOR POLYNUCLEOTIDE DELIVERY | INTEZYNE TECHNOLOGIES, INCORPORATED (US) | 2011-09-15 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120148631-A1 | PEGYLATED POLYPLEXES FOR POLYNUCLEOTIDE DELIVERY | PARN, PUF60, PARG | CASP2 4848/4885DNM1 295/4885CTSD 4392/4885 |
| US-20120237565-A1 | PEGYLATED POLYPLEXES CONTAINING TWO OR MORE DIFFERENT POLYMERS FOR POLYNUCLEOTIDE DELIVERY | PARN, PARG, PUF60 | CASP2 4779/4885DNM1 430/4885CTSD 4392/4885 |
| US-20110229528-A1 | PEGYLATED POLYPLEXES FOR POLYNUCLEOTIDE DELIVERY | PARN, PUF60, PARG | CASP2 4848/4885DNM1 295/4885CTSD 4392/4885 |
| US-20110256227-A1 | CONTROLLED POLYPLEX ASSEMBLY | PARG, PARN, PUF60 | CASP2 4774/4885DNM1 787/4885CTSD 4722/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.