Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRM5 | P41594 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | GLA | P06280 | 1/20 | 0.33 |
| ▸ | BRD4 | O60885 | 1/20 | 0.32 |
| ▸ | PIM1 | P11309 | 1/20 | 0.32 |
| ▸ | PIM2 | Q9P1W9 | 1/20 | 0.32 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.32 |
| ▸ | KDM4C | Q9H3R0 | 1/20 | 0.31 |
| ▸ | NAMPT | P43490 | 1/20 | 0.31 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.31 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.31 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.31 |
| ▸ | SLC6A2 | P23975 | 2/20 | 0.31 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.31 |
| ▸ | HTR1A | P08908 | 1/20 | 0.31 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.31 |
| ▸ | FFAR4 | Q5NUL3 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9918532 | 0.80 | GRM5 (0.40) | GRM5ALDH1A1SMN1; SMN2KDM4EGLA | |
| SCHEMBL21056431 | 0.65 | CRBN (0.49) | GRM5ALDH1A1SMN1; SMN2SLC6A2SLC6A4 | |
| SCHEMBL5335460 | 0.65 | HTR1A (0.71) | GRM5SLC6A2SLC6A4HTR1ASLC6A3 | |
| SCHEMBL3205934 | 0.58 | LMNA (0.45) | GRM5ALDH1A1SMN1; SMN2KDM4EPIM1 | |
| SCHEMBL5332097 | 0.56 | LMNA (0.53) | GRM5ALDH1A1SMN1; SMN2MAPK1HSD17B10 | |
| SCHEMBL11477740 | 0.56 | TDP1 (0.53) | GRM5ALDH1A1SMN1; SMN2P2RX7MAPK1 | |
| SCHEMBL5318974 | 0.56 | LMNA (0.53) | GRM5ALDH1A1SMN1; SMN2MAPK1HSD17B10 | |
| SCHEMBL11483460 | 0.56 | LMNA (0.53) | GRM5ALDH1A1SMN1; SMN2KDM4EMAPK1 | |
| SCHEMBL11478665 | 0.56 | LMNA (0.53) | GRM5ALDH1A1SMN1; SMN2KDM4EMAPK1 | |
| SCHEMBL9922005 | 0.56 | LMNA (0.53) | GRM5ALDH1A1SMN1; SMN2KDM4EMAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20120149662-A1 | Heterocyclic Compounds as Janus Kinase Inhibitors | BIOCRYST PHARMACEUTICALS, INC. (US) | 2012-06-14 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120149662-A1 | Heterocyclic Compounds as Janus Kinase Inhibitors | JAK2, JAK1, JAK3 | GRM5 3096/4885ALDH1A1 1507/4885SMN1; SMN2 4199/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.