Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OPRK1 | P41145 | 5/20 | 0.48 |
| ▸ | SCN10A | Q9Y5Y9 | 3/20 | 0.42 |
| ▸ | ROCK2 | O75116 | 3/20 | 0.40 |
| ▸ | ROCK1 | Q13464 | 3/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.39 |
| ▸ | NPC1 | O15118 | 1/20 | 0.39 |
| ▸ | RAB9A | P51151 | 1/20 | 0.39 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 3/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | P2RY12 | Q9H244 | 1/20 | 0.38 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.38 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.38 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.38 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.38 |
| ▸ | TP53 | P04637 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9923484 | 0.89 | PTGER4 (0.45) | OPRK1SCN10AROCK2ROCK1TP53 | |
| SCHEMBL9900923 | 0.85 | HSD17B13 (0.38) | OPRK1SCN10A | |
| SCHEMBL9900898 | 0.84 | MEN1 (0.40) | ROCK2ROCK1KDM4ESMN1; SMN2NPC1 | |
| SCHEMBL9901382 | 0.84 | CYP3A4 (0.43) | OPRK1ROCK2ROCK1KDM4ESMN1; SMN2 | |
| SCHEMBL9901212 | 0.84 | OPRK1 (0.45) | OPRK1ROCK2ROCK1KDM4ESMN1; SMN2 | |
| SCHEMBL9900018 | 0.83 | OPRK1 (0.44) | OPRK1KDM4ESMN1; SMN2MAPTOPRD1 | |
| SCHEMBL9900687 | 0.82 | SCN9A (0.43) | OPRK1SMN1; SMN2MAPTCYP2C9CYP2C19 | |
| SCHEMBL9900978 | 0.82 | KDM4E (0.46) | OPRK1ROCK2ROCK1KDM4ESMN1; SMN2 | |
| SCHEMBL9901791 | 0.82 | F9 (0.37) | OPRK1ROCK2ROCK1SMN1; SMN2NPC1 | |
| SCHEMBL9901802 | 0.82 | SCN9A (0.39) | OPRK1SMN1; SMN2MAPTCYP2C9CYP2C19 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2649061-B1 | PYRIDINE AMIDE DERIVATIVES AS EP4 RECEPTOR ANTAGONISTS | Rottapharm Biotech Srl (IT) | 2015-05-13 | — | — | EP | disclosed |
| WO-2012076063-A1 | PYRIDINE AMIDE DERIVATIVES AS EP4 RECEPTOR ANTAGONISTS | ROTTAPHARM S.P.A. (IT) | 2012-06-14 | — | — | WO | disclosed |