Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGER4 | P35408 | 7/20 | 0.45 |
| ▸ | PTGDR | Q13258 | 2/20 | 0.45 |
| ▸ | SCN10A | Q9Y5Y9 | 3/20 | 0.43 |
| ▸ | CNR2 | P34972 | 1/20 | 0.42 |
| ▸ | SERPINE1 | P05121 | 2/20 | 0.40 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.39 |
| ▸ | TBXA2R | P21731 | 1/20 | 0.39 |
| ▸ | PTGER1 | P34995 | 1/20 | 0.39 |
| ▸ | PTGFR | P43088 | 1/20 | 0.39 |
| ▸ | PTGER3 | P43115 | 1/20 | 0.39 |
| ▸ | PTGER2 | P43116 | 1/20 | 0.39 |
| ▸ | SLC6A9 | P48067 | 1/20 | 0.38 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.38 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.38 |
| ▸ | F10 | P00742 | 1/20 | 0.37 |
| ▸ | TP53 | P04637 | 1/20 | 0.37 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.37 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.37 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.37 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9923402 | 0.89 | OPRK1 (0.48) | SCN10AOPRK1ROCK2ROCK1TP53 | |
| SCHEMBL9900655 | 0.84 | PTGER4 (0.43) | PTGER4PTGDRSCN10ATBXA2RPTGER1 | |
| SCHEMBL9900575 | 0.83 | LMNA (0.46) | PTGER4PTGDRSCN10AOPRK1SLC6A9 | |
| SCHEMBL9900633 | 0.83 | LMNA (0.46) | PTGER4PTGDRSCN10AOPRK1SLC6A9 | |
| SCHEMBL9900804 | 0.83 | PTGER4 (0.41) | PTGER4PTGDRTBXA2RPTGER1PTGFR | |
| SCHEMBL9900285 | 0.82 | PTGER4 (0.42) | PTGER4PTGDROPRK1 | |
| SCHEMBL9900684 | 0.81 | SCN9A (0.45) | PTGER4PTGDRSLC6A9 | |
| SCHEMBL9900441 | 0.81 | PTGER4 (0.45) | PTGER4PTGDRSCN10APTGER2 | |
| SCHEMBL9900176 | 0.81 | PTGER4 (0.41) | PTGER4PTGDRSCN10ATBXA2RPTGER1 | |
| SCHEMBL9900688 | 0.81 | PTGER4 (0.41) | PTGER4PTGDRTBXA2RPTGER1PTGFR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2649061-B1 | PYRIDINE AMIDE DERIVATIVES AS EP4 RECEPTOR ANTAGONISTS | Rottapharm Biotech Srl (IT) | 2015-05-13 | — | — | EP | disclosed |
| WO-2012076063-A1 | PYRIDINE AMIDE DERIVATIVES AS EP4 RECEPTOR ANTAGONISTS | ROTTAPHARM S.P.A. (IT) | 2012-06-14 | — | — | WO | disclosed |