Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 2/20 | 0.42 |
| ▸ | POLB | P06746 | 2/20 | 0.42 |
| ▸ | RAB9A | P51151 | 2/20 | 0.42 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.41 |
| ▸ | CHRNB4 | P30926 | 1/20 | 0.41 |
| ▸ | CHRNA3 | P32297 | 1/20 | 0.41 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
| ▸ | HTT | P42858 | 3/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.36 |
| ▸ | PRKCA | P17252 | 1/20 | 0.36 |
| ▸ | PRKCQ | Q04759 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.36 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9900783 | 0.82 | LMNA (0.40) | POLBCHRNB2CHRNB4CHRNA3CHRNA4 | |
| SCHEMBL10820261 | 0.82 | NPC1 (0.43) | NPC1POLBRAB9AGAAHTT | |
| SCHEMBL22725021 | 0.82 | HDAC1 (0.41) | CHRNB2CHRNB4CHRNA3CHRNA4GAA | |
| Hydrochloric Acid SCHEMBL71413 | 0.81 | ACKR3 (0.42) | NPC1POLBRAB9AGAAHTT | |
| SCHEMBL19262329 | 0.77 | GAA (0.47) | NPC1POLBRAB9ACHRNB2CHRNA4 | |
| SCHEMBL22725025 | 0.76 | HCAR3 (0.49) | RAB9AGAAHTTLMNAL3MBTL1 | |
| SCHEMBL14506682 | 0.75 | GAA (0.44) | NPC1POLBRAB9AGAAHTT | |
| SCHEMBL6928194 | 0.73 | ACKR3 (0.49) | NPC1POLBRAB9AGAALMNA | |
| SCHEMBL1413470 | 0.72 | DDB1 (0.42) | NPC1POLBRAB9ACHRNB2CHRNB4 | |
| Trifluoroacetic Acid SCHEMBL15565383 | 0.72 | NPC1 (0.44) | NPC1POLBRAB9AGAAHTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012076063-A1 | PYRIDINE AMIDE DERIVATIVES AS EP4 RECEPTOR ANTAGONISTS | ROTTAPHARM S.P.A. (IT) | 2012-06-14 | — | — | WO | disclosed |