Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TRPA1 | O75762 | 3/20 | 0.46 |
| ▸ | TSHR | P16473 | 2/20 | 0.42 |
| ▸ | HDAC4 | P56524 | 2/20 | 0.38 |
| ▸ | HDAC2 | Q92769 | 2/20 | 0.38 |
| ▸ | HDAC8 | Q9BY41 | 2/20 | 0.38 |
| ▸ | GABRA1 | P14867 | 4/20 | 0.37 |
| ▸ | GABRB2 | P47870 | 3/20 | 0.37 |
| ▸ | CA1 | P00915 | 4/20 | 0.35 |
| ▸ | CA2 | P00918 | 4/20 | 0.35 |
| ▸ | CA9 | Q16790 | 2/20 | 0.35 |
| ▸ | CA12 | O43570 | 1/20 | 0.35 |
| ▸ | CA7 | P43166 | 1/20 | 0.35 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.35 |
| ▸ | HPGD | P15428 | 3/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.35 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.35 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.35 |
| ▸ | LMNA | P02545 | 2/20 | 0.35 |
| ▸ | ADAMTS4 | O75173 | 1/20 | 0.35 |
| ▸ | EGFR | P00533 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6325213 | 0.83 | TSHR (0.47) | TRPA1TSHRHDAC4HDAC2HDAC8 | |
| SCHEMBL9900083 | 0.79 | TP53 (0.36) | TRPA1TSHRCA1CA2HPGD | |
| SCHEMBL24263525 | 0.78 | LMNA (0.41) | TRPA1TSHRCA1CA2HPGD | |
| SCHEMBL3576125 | 0.77 | TSHR (0.61) | TRPA1TSHRHDAC4HDAC2HDAC8 | |
| SCHEMBL14576084 | 0.77 | TSHR (0.67) | TRPA1TSHRHDAC4HDAC2HDAC8 | |
| SCHEMBL31545167 | 0.76 | ALDH1A1 (0.46) | TSHRALDH1A1MAPTHTTATM | |
| SCHEMBL9281627 | 0.76 | ALDH1A1 (0.46) | TSHRALDH1A1MAPTHTTATM | |
| SCHEMBL31545285 | 0.76 | ALDH1A1 (0.46) | TSHRALDH1A1MAPTHTTATM | |
| SCHEMBL28343869 | 0.76 | TSHR (0.59) | TRPA1TSHRHDAC4HDAC2HDAC8 | |
| SCHEMBL676779 | 0.72 | TSHR (0.50) | TSHRHDAC4HDAC2HDAC8GABRA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012076877-A1 | HYDANTOIN DERIVATIVES USEFUL AS KV3 INHIBITORS | AUTIFONY THERAPEUTICS LIMITED (GB) | 2012-06-14 | — | — | WO | disclosed |