Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACKR3 | P25106 | 3/20 | 0.44 |
| ▸ | AR | P10275 | 3/20 | 0.43 |
| ▸ | MCHR1 | Q99705 | 5/20 | 0.42 |
| ▸ | GRM5 | P41594 | 1/20 | 0.41 |
| ▸ | MAPK11 | Q15759 | 1/20 | 0.40 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.40 |
| ▸ | CCNE1 | P24864 | 1/20 | 0.40 |
| ▸ | CDK2 | P24941 | 1/20 | 0.40 |
| ▸ | CRHR1 | P34998 | 1/20 | 0.40 |
| ▸ | BRAF | P15056 | 1/20 | 0.40 |
| ▸ | NUDT1 | P36639 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9924169 | 0.86 | CRHR1 (0.49) | GRM5L3MBTL1CRHR1 | |
| SCHEMBL9924422 | 0.84 | KCNQ3 (0.42) | MCHR1GRM5MAPT | |
| SCHEMBL17206698 | 0.83 | GRM5 (0.51) | ACKR3GRM5MAPT | |
| SCHEMBL9924260 | 0.83 | MEN1 (0.46) | ACKR3MAPTL3MBTL1CRHR1 | |
| SCHEMBL17206628 | 0.82 | MEN1 (0.45) | ACKR3MAPTCRHR1 | |
| SCHEMBL17206687 | 0.82 | KCNQ3 (0.45) | ARGRM5MAPTBRAF | |
| SCHEMBL9924424 | 0.81 | TRPV1 (0.45) | ACKR3MAPT | |
| SCHEMBL9924144 | 0.81 | MEN1 (0.42) | MAPT | |
| SCHEMBL9924171 | 0.80 | DRD2 (0.47) | MAPT | |
| SCHEMBL9924128 | 0.79 | MEN1 (0.41) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9169199-B2 | Cycloalkyl guanidine F1F0-ATPase inhibitors and therapeutic uses thereof | LYCERA CORPORATION (US) | 2015-10-27 | — | — | US | disclosed |
| WO-2012078867-A2 | CYCLOALKYL GUANIDINE F1F0-ATPASE INHIBITORS AND THERAPEUTIC USES THEREOF | LYCERA CORPORATION (US) | 2012-06-14 | — | — | WO | disclosed |