Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Propylene Glycol. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.56 |
| ▸ | OR51E2 | Q9H255 | 1/20 | 0.39 |
| ▸ | TP53 | P04637 | 1/20 | 0.38 |
| ▸ | TSHR | P16473 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 2/20 | 0.35 |
| ▸ | SLC22A6 | Q4U2R8 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.34 |
| ▸ | RNPEP | Q9H4A4 | 1/20 | 0.33 |
| ▸ | FFAR3 | O14843 | 1/20 | 0.33 |
| ▸ | ENPEP | Q07075 | 1/20 | 0.33 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Propylene Glycol SCHEMBL451462 | 1.00 | TDP1 (0.56) | TDP1OR51E2TP53TSHRLMNA | |
| Propylene Glycol SCHEMBL27454781 | 0.95 | TDP1 (0.50) | TDP1OR51E2TP53TSHRLMNA | |
| Thioglycolic Acid SCHEMBL110271 | 0.85 | — | — | |
| Thioglycolic Acid SCHEMBL5074469 | 0.85 | TP53 (0.44) | TDP1TP53TSHRLMNASLC22A6 | |
| Thioglycolic Acid SCHEMBL32681731 | 0.83 | TSHR (0.38) | TDP1OR51E2TSHRLMNAALDH1A1 | |
| Thioglycolic Acid SCHEMBL11586774 | 0.83 | ALDH1A1 (0.39) | TDP1TP53LMNASLC22A6ALDH1A1 | |
| Acrylic Acid SCHEMBL27663261 | 0.83 | TDP1 (0.39) | TDP1TSHRLMNA | |
| Thioglycolic Acid SCHEMBL4528557 | 0.82 | — | — | |
| Propylene Glycol SCHEMBL28346548 | 0.82 | TDP1 (0.62) | TDP1OR51E2TP53TSHRSLC22A6 | |
| Thioglycolic Acid SCHEMBL27947118 | 0.82 | OR51E2 (0.43) | OR51E2TSHRLMNASLC22A6ENPEP |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 92 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20220227915-A1 | PREPARATION METHOD FOR POLYURETHANE OPTICAL RESIN AND APPLICATIONS THEREOF | WANHUA CHEMICAL GROUP CO., LTD. (CN) | 2022-07-21 | — | — | US | claimed |
| EP-4006076-A1 | PREPARATION METHOD FOR POLYURETHANE OPTICAL RESIN AND APPLICATIONS THEREOF | Wanhua Chemical Group Co., Ltd. (CN) | 2022-06-01 | — | — | EP | claimed |
| EP-3158012-B1 | FIRE-RESISTANT COMPOUND AND ITS UTILISATION | HILTI AG (LI) | 2020-02-19 | — | — | EP | claimed |
| US-10392516-B2 | Fire protection composition and use thereof | HILTI AKTIENGESELLSCHAFT (LI) | 2019-08-27 | — | — | US | claimed |
| US-10287504-B2 | Composition that forms an insulating layer and use thereof | HILTI AKTIENGESELLSCHAFT (LI) | 2019-05-14 | — | — | US | claimed |
| US-10000659-B2 | Insulating layer-forming composition and use thereof | HILTI AKTIENGESELLSCHAFT (LI) | 2018-06-19 | — | — | US | claimed |
| EP-2935475-B1 | INSULATING LAYER-FORMING COMPOSITION AND USE THEREOF | HILTI AG (LI) | 2017-07-19 | — | — | EP | claimed |
| US-20170145223-A1 | Fireproof Composition and Use Thereof | HILTI AKTIENGESELLSCHAFT (LI) | 2017-05-25 | — | — | US | claimed |
| US-20170130066-A1 | Fire Protection Composition and Use Thereof | HILTI AKTIENGESELLSCHAFT (LI) | 2017-05-11 | — | — | US | claimed |
| US-20170130068-A1 | Fireprotection Composition and Use Thereof | HILTI AKTIENGESELLSCHAFT (LI) | 2017-05-11 | — | — | US | claimed |
| US-20150337160-A1 | INSULATING LAYER-FORMING COMPOSITION AND THE USE THEREOF | HILTI AKTIENGESELLSCHAFT (LI) | 2015-11-26 | — | — | US | claimed |
| US-20150299578-A1 | COMPOSITION THAT FORMS AN INSULATING LAYER AND USE THEREOF | HILTI AKTIENGESELLSCHAFT (LI) | 2015-10-22 | — | — | US | claimed |
| US-20150275031-A1 | INSULATING LAYER-FORMING COMPOSITION AND USE THEREOF | HILTI AKTIENGESELLSCHAFT (LI) | 2015-10-01 | — | — | US | claimed |
| US-4093780-A | ESTERS AND POLYESTERS OF THIOGLYCOLIC ACID | NORANDA MINES LIMITED (CA) | 1978-06-06 | — | — | US | claimed |
| US-12501540-B2 | Electronic device and manufacturing method thereof | FUJIFILM CORPORATION (JP) | 2025-12-16 | — | — | US | disclosed |
| US-12492293-B2 | Multi-component systems for preparing foamed products | ARKEMA FRANCE (FR) | 2025-12-09 | — | — | US | disclosed |
| US-12451440-B2 | Electronic device and manufacturing method thereof | FUJIFILM CORPORATION (JP) | 2025-10-21 | — | — | US | disclosed |
| US-5475074-A | Copolamerizable monomers containing vinyl benzyl compound, 2,4-diphenyl-4-methyl-1-pentene and an acrylic momomer; also contains mercapto, hindered phenol and azo compounds; high refractive index, heat and radiation resistance | TOKUYAMA CORPORATION (JP) | 1995-12-12 | — | — | US | disclosed |
| EP-0609061-A2 | Polymerizable composition, polymer, organic glass and ophthalmic lens | TOKUYAMA CORPORATION (JP) | 1994-08-03 | — | — | EP | disclosed |
| US-4093780-A | ESTERS AND POLYESTERS OF THIOGLYCOLIC ACID | NORANDA MINES LIMITED (CA) | 1978-06-06 | — | — | US | disclosed |