Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Propylene Glycol. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.56 |
| ▸ | OR51E2 | Q9H255 | 1/20 | 0.39 |
| ▸ | TP53 | P04637 | 1/20 | 0.38 |
| ▸ | TSHR | P16473 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 2/20 | 0.35 |
| ▸ | SLC22A6 | Q4U2R8 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.34 |
| ▸ | RNPEP | Q9H4A4 | 1/20 | 0.33 |
| ▸ | FFAR3 | O14843 | 1/20 | 0.33 |
| ▸ | ENPEP | Q07075 | 1/20 | 0.33 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Propylene Glycol SCHEMBL99242 | 1.00 | TDP1 (0.56) | TDP1OR51E2TP53TSHRLMNA | |
| Propylene Glycol SCHEMBL27454781 | 0.95 | TDP1 (0.50) | TDP1OR51E2TP53TSHRLMNA | |
| Thioglycolic Acid SCHEMBL110271 | 0.85 | — | — | |
| Thioglycolic Acid SCHEMBL5074469 | 0.85 | TP53 (0.44) | TDP1TP53TSHRLMNASLC22A6 | |
| Thioglycolic Acid SCHEMBL32681731 | 0.83 | TSHR (0.38) | TDP1OR51E2TSHRLMNAALDH1A1 | |
| Thioglycolic Acid SCHEMBL11586774 | 0.83 | ALDH1A1 (0.39) | TDP1TP53LMNASLC22A6ALDH1A1 | |
| Acrylic Acid SCHEMBL27663261 | 0.83 | TDP1 (0.39) | TDP1TSHRLMNA | |
| Thioglycolic Acid SCHEMBL4528557 | 0.82 | — | — | |
| Propylene Glycol SCHEMBL28346548 | 0.82 | TDP1 (0.62) | TDP1OR51E2TP53TSHRSLC22A6 | |
| Thioglycolic Acid SCHEMBL27947118 | 0.82 | OR51E2 (0.43) | OR51E2TSHRLMNASLC22A6ENPEP |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 83 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20230329991-A1 | PERMANENT HAIR SHAPING COMPOSITION | WELLA GERMANY GMBH (DE) | 2023-10-19 | — | — | US | claimed |
| EP-4216912-A1 | PERMANENT HAIR SHAPING COMPOSITION | Wella Germany GmbH (DE) | 2023-08-02 | — | — | EP | claimed |
| CN-116390709-A | Permanent hair shaping composition | 威娜德国有限责任公司 | 2023-07-04 | — | — | CN | claimed |
| WO-2022063917-A1 | PERMANENT HAIR SHAPING COMPOSITION | HFC PRESTIGE SERVICE GERMANY GMBH (DE) | 2022-03-31 | — | — | WO | claimed |
| EP-2509566-B2 | PROCESS FOR PERMANENT SHAPING OF HUMAN HAIR | KAO GERMANY GMBH (DE) | 2022-03-09 | — | — | EP | claimed |
| EP-2509566-B1 | PROCESS FOR PERMANENT SHAPING OF HUMAN HAIR | KAO GERMANY GMBH (DE) | 2018-08-22 | — | — | EP | claimed |
| US-9554980-B2 | Composition and process for permanent shaping of human hair | KAO GERMANY GMBH (DE) | 2017-01-31 | — | — | US | claimed |
| EP-2515844-B1 | PROCESS FOR PERMANENT SHAPING OF HUMAN HAIR | KAO GERMANY GMBH (DE) | 2016-10-26 | — | — | EP | claimed |
| EP-2658519-B1 | COMPOSITION AND PROCESS FOR PERMANENT SHAPING OF HUMAN HAIR | KAO GERMANY GMBH (DE) | 2016-07-20 | — | — | EP | claimed |
| US-20140246042-A1 | Process for Permanent Shaping of Human Hair | KAO GERMANY GMBH (DE) | 2014-09-04 | — | — | US | claimed |
| US-8753616-B2 | Process for permanent shaping of human hair | KAO GERMANY GMBH (DE) | 2014-06-17 | — | — | US | claimed |
| US-8747825-B2 | Process for permanent shaping of human hair | KAO GERMANY GMBH (DE) | 2014-06-10 | — | — | US | claimed |
| EP-2191865-B1 | Process for colouring and straightening keratin fibres | KAO GERMANY GMBH (DE) | 2013-10-23 | — | — | EP | claimed |
| US-20120255573-A1 | PROCESS FOR PERMANENT SHAPING OF HUMAN HAIR | KAO GERMANY GMBH (DE) | 2012-10-11 | — | — | US | claimed |
| US-20120234339-A1 | PROCESS FOR PERMANENT SHAPING OF HUMAN HAIR | KAO GERMANY GMBH (DE) | 2012-09-20 | — | — | US | claimed |
| EP-2468250-A1 | Composition and process for permanent shaping of human hair | KPSS-Kao Professional Salon Services GmbH (DE) | 2012-06-27 | — | — | EP | claimed |
| EP-2338471-A1 | Process for permanent shaping human hair | KPSS-Kao Professional Salon Services GmbH (DE) | 2011-06-29 | — | — | EP | claimed |
| EP-2332515-A1 | Process for permanent shaping of human hair | KPSS-Kao Professional Salon Services GmbH (DE) | 2011-06-15 | — | — | EP | claimed |
| EP-2191864-A1 | Process for colouring and straightening keratin fibres | KPSS-Kao Professional Salon Services GmbH (DE) | 2010-06-02 | — | — | EP | claimed |
| EP-2191865-A1 | Process for colouring and straightening keratin fibres | KPSS-Kao Professional Salon Services GmbH (DE) | 2010-06-02 | — | — | EP | claimed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120255573-A1 | PROCESS FOR PERMANENT SHAPING OF HUMAN HAIR | POLR1C, PLOD2, SMOX | TDP1 2434/4885OR51E2 1402/4885TP53 2530/4885 |
| US-20140246042-A1 | Process for Permanent Shaping of Human Hair | POLR1C, PRKDC, PRKACG | TDP1 3126/4885OR51E2 2875/4885TP53 2231/4885 |
| US-20120234339-A1 | PROCESS FOR PERMANENT SHAPING OF HUMAN HAIR | POLR1C, PRKDC, PRKACG | TDP1 3126/4885OR51E2 2875/4885TP53 2231/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.