Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 3/20 | 0.54 |
| ▸ | UCHL1 | P09936 | 1/20 | 0.49 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.48 |
| ▸ | HPGD | P15428 | 3/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.48 |
| ▸ | GAA | P10253 | 3/20 | 0.48 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.48 |
| ▸ | GLA | P06280 | 2/20 | 0.48 |
| ▸ | USP2 | O75604 | 1/20 | 0.48 |
| ▸ | CASP1 | P29466 | 1/20 | 0.48 |
| ▸ | CASP7 | P55210 | 1/20 | 0.48 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.48 |
| ▸ | TP53 | P04637 | 2/20 | 0.47 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.47 |
| ▸ | LMNA | P02545 | 2/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.47 |
| ▸ | MEN1 | O00255 | 2/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.47 |
| ▸ | NPC1 | O15118 | 2/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18546530 | 0.89 | ALDH1A1 (0.54) | MAPTKDM4EHPGDALDH1A1GAA | |
| SCHEMBL22435184 | 0.88 | MAPT (0.56) | MAPTUCHL1MAPK1KDM4EHPGD | |
| SCHEMBL15075363 | 0.86 | MAPT (0.55) | MAPTUCHL1MAPK1KDM4EHPGD | |
| SCHEMBL28563833 | 0.86 | MAPK1 (0.50) | MAPTMAPK1KDM4EHPGDALDH1A1 | |
| SCHEMBL14357208 | 0.86 | MAPK1 (0.65) | MAPTMAPK1KDM4EHPGDALDH1A1 | |
| SCHEMBL27215188 | 0.85 | MAPT (0.54) | MAPTUCHL1MAPK1KDM4EHPGD | |
| SCHEMBL22412886 | 0.84 | MAPT (0.53) | MAPTUCHL1MAPK1KDM4EHPGD | |
| SCHEMBL16178685 | 0.81 | MAPT (0.50) | MAPTUCHL1MAPK1KDM4EHPGD | |
| SCHEMBL31511067 | 0.81 | MAPT (0.49) | MAPTUCHL1MAPK1KDM4EHPGD | |
| SCHEMBL22609338 | 0.81 | UCHL1 (0.54) | MAPTUCHL1MAPK1KDM4EHPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012075678-A1 | SUBSTITUTED THIAZOLYL PYRAZOLO PYRIDINE COMPOUND AND MEDICINAL USE THEREOF | 中国人民解放军军事医学科学院毒物药物研究所 (CN) | 2012-06-14 | — | — | WO | disclosed |