Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR5A | P47898 | 13/20 | 0.47 |
| ▸ | PTGES | O14684 | 2/20 | 0.41 |
| ▸ | DOT1L | Q8TEK3 | 1/20 | 0.38 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.36 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.36 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.36 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.36 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.36 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.36 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.36 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.36 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.36 |
| ▸ | HDAC9 | Q9UKV0 | 1/20 | 0.36 |
| ▸ | HDAC5 | Q9UQL6 | 1/20 | 0.36 |
| ▸ | TGFBR1 | P36897 | 2/20 | 0.36 |
| ▸ | GAK | O14976 | 1/20 | 0.36 |
| ▸ | RIPK2 | O43353 | 1/20 | 0.36 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.36 |
| ▸ | KDR | P35968 | 1/20 | 0.36 |
| ▸ | ACVR1B | P36896 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9907793 | 0.88 | HTR5A (0.63) | HTR5A | |
| SCHEMBL9907344 | 0.87 | HTR5A (0.43) | HTR5APTGESDOT1LTGFBR1GAK | |
| SCHEMBL9907340 | 0.83 | TGFBR1 (0.50) | HTR5APTGESTGFBR1MAPK14NPC1 | |
| SCHEMBL9907801 | 0.79 | HTR5A (0.54) | HTR5A | |
| SCHEMBL9907363 | 0.78 | DOT1L (0.44) | DOT1LTGFBR1GAKRIPK2MAP4K4 | |
| SCHEMBL12874617 | 0.78 | SLC2A1 (0.46) | PTGESDOT1LTGFBR1GAKRIPK2 | |
| SCHEMBL9907790 | 0.75 | HTR5A (0.62) | HTR5A | |
| SCHEMBL9907359 | 0.74 | TGFBR1 (0.52) | DOT1LTGFBR1 | |
| SCHEMBL9907795 | 0.74 | HTR5A (0.58) | HTR5A | |
| SCHEMBL9907803 | 0.73 | HTR5A (0.54) | HTR5A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2463276-A1 | NITROGENOUS-RING ACYLGUANIDINE DERIVATIVE | Astellas Pharma Inc. (JP) | 2012-06-13 | — | — | EP | disclosed |