Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR5A | P47898 | 8/20 | 0.38 |
| ▸ | PTGDR2 | Q9Y5Y4 | 4/20 | 0.38 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.35 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.35 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.35 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.35 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.35 |
| ▸ | HTR7 | P34969 | 4/20 | 0.34 |
| ▸ | HTR2B | P41595 | 4/20 | 0.34 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.32 |
| ▸ | PIK3R2 | O00459 | 1/20 | 0.31 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.31 |
| ▸ | MAPK3 | P27361 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9907837 | 0.89 | HTR5A (0.47) | HTR5APTGDR2HTR7HTR2B | |
| SCHEMBL12875077 | 0.89 | HTR5A (0.45) | HTR5APTGDR2CYP2C9PTGS1SLC6A4 | |
| SCHEMBL12874635 | 0.87 | HTR5A (0.41) | HTR5APTGDR2 | |
| SCHEMBL15500584 | 0.86 | PTGDR2 (0.35) | HTR5APTGDR2CYP2C9PTGS1SLC6A4 | |
| SCHEMBL12875043 | 0.85 | HTR5A (0.45) | HTR5APTGDR2CYP2C9PTGS1SLC6A4 | |
| SCHEMBL12874645 | 0.84 | HTR5A (0.38) | HTR5A | |
| SCHEMBL9907822 | 0.83 | HTR5A (0.55) | HTR5APTGDR2HTR7HTR2B | |
| SCHEMBL12874648 | 0.83 | CDC7 (0.37) | HTR5APTGDR2CYP2C9CYP2C19 | |
| SCHEMBL12874646 | 0.82 | GRM2 (0.36) | HTR5AMAPK1 | |
| SCHEMBL9907464 | 0.80 | PTGDR2 (0.46) | PTGDR2CYP2C9PTGS1SLC6A4CYP2C19 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2463276-A1 | NITROGENOUS-RING ACYLGUANIDINE DERIVATIVE | Astellas Pharma Inc. (JP) | 2012-06-13 | — | — | EP | disclosed |