Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR5A | P47898 | 8/20 | 0.60 |
| ▸ | TNF | P01375 | 1/20 | 0.35 |
| ▸ | SLC22A12 | Q96S37 | 2/20 | 0.34 |
| ▸ | S1PR3 | Q99500 | 2/20 | 0.34 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.34 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.34 |
| ▸ | MTOR | P42345 | 1/20 | 0.34 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.34 |
| ▸ | PRKDC | P78527 | 1/20 | 0.34 |
| ▸ | ATM | Q13315 | 1/20 | 0.34 |
| ▸ | ATR | Q13535 | 1/20 | 0.34 |
| ▸ | MAP3K8 | P41279 | 1/20 | 0.34 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.33 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.33 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.33 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.33 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.33 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.33 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.33 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9909288 | 0.89 | HTR5A (0.77) | HTR5APIK3CAPIK3CBMTORPIK3CG | |
| SCHEMBL9909253 | 0.89 | HTR5A (0.55) | HTR5ATNFSLC22A12S1PR3PIK3CA | |
| SCHEMBL12875061 | 0.86 | HTR5A (0.64) | HTR5ATNFPIK3CAPIK3CBMTOR | |
| SCHEMBL9925448 | 0.85 | HTR5A (0.52) | HTR5ATNFPIK3CAPIK3CBMTOR | |
| SCHEMBL9909242 | 0.75 | HTR5A (0.59) | HTR5APIK3CAPIK3CBMTORPIK3CG | |
| SCHEMBL9907842 | 0.75 | HTR5A (1.00) | HTR5A | |
| SCHEMBL9907497 | 0.74 | HTR5A (0.72) | HTR5A | |
| SCHEMBL9909265 | 0.73 | PDE5A (0.42) | HTR5ASLC22A12EGLN1 | |
| SCHEMBL9907888 | 0.73 | HTR5A (0.81) | HTR5A | |
| SCHEMBL9925369 | 0.73 | HTR5A (0.48) | HTR5AHDAC3HDAC4HDAC1HDAC7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2463276-A1 | NITROGENOUS-RING ACYLGUANIDINE DERIVATIVE | Astellas Pharma Inc. (JP) | 2012-06-13 | — | — | EP | disclosed |