Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE5A | O76074 | 4/20 | 0.42 |
| ▸ | PLAU | P00749 | 2/20 | 0.42 |
| ▸ | PLG | P00747 | 1/20 | 0.42 |
| ▸ | HTR5A | P47898 | 1/20 | 0.41 |
| ▸ | MRGPRX4 | Q96LA9 | 1/20 | 0.41 |
| ▸ | SLC22A12 | Q96S37 | 1/20 | 0.40 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.40 |
| ▸ | EGLN1 | Q9GZT9 | 3/20 | 0.40 |
| ▸ | LRRK2 | Q5S007 | 2/20 | 0.39 |
| ▸ | EIF4EBP1 | Q13541 | 1/20 | 0.39 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.39 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.39 |
| ▸ | MALT1 | Q9UDY8 | 1/20 | 0.38 |
| ▸ | NR3C2 | P08235 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9909169 | 0.91 | PDE5A (0.45) | PDE5APLAUHTR5AMRGPRX4SCN9A | |
| SCHEMBL9909242 | 0.87 | HTR5A (0.59) | PDE5APLAUPLGHTR5ASCN9A | |
| SCHEMBL9909170 | 0.86 | TTR (0.47) | PLAUPLGHTR5AMRGPRX4SCN9A | |
| SCHEMBL9909253 | 0.84 | HTR5A (0.55) | HTR5AMRGPRX4SLC22A12EGLN1EIF4EBP1 | |
| SCHEMBL9925238 | 0.84 | HTR5A (0.49) | PDE5APLAUPLGHTR5ASCN9A | |
| SCHEMBL16509491 | 0.83 | SLC22A12 (0.43) | MRGPRX4SLC22A12SCN9AEGLN1CYP11B1 | |
| SCHEMBL9909283 | 0.82 | PLAU (0.49) | PLAUPLGHTR5AMRGPRX4SLC22A12 | |
| SCHEMBL9909257 | 0.81 | SLC22A12 (0.42) | HTR5AMRGPRX4SLC22A12SCN9AEGLN1 | |
| SCHEMBL9909156 | 0.81 | SCN9A (0.49) | PDE5ASLC22A12SCN9AEGLN1CYP11B1 | |
| SCHEMBL9909267 | 0.80 | SLC22A12 (0.52) | PLAUHTR5AMRGPRX4SLC22A12EIF4EBP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8853242-B2 | Nitrogenous-ring acylguanidine derivative | ASTELLAS PHARMA INC. (JP) | 2014-10-07 | — | — | US | disclosed |
| EP-2463276-B1 | NITROGENOUS-RING ACYLGUANIDINE DERIVATIVE | ASTELLAS PHARMA INC (JP) | 2014-03-12 | — | — | EP | disclosed |
| US-20120142727-A1 | NITROGENOUS-RING ACYLGUANIDINE DERIVATIVE | ASTELLAS PHARMA INC. (JP) | 2012-06-07 | — | — | US | disclosed |
| WO-2011016504-A1 | NITROGENOUS-RING ACYLGUANIDINE DERIVATIVE | アステラス製薬株式会社 (JP) | 2011-02-10 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120142727-A1 | NITROGENOUS-RING ACYLGUANIDINE DERIVATIVE | HTR5A, HTR2A, HTR1E | PDE5A 82/4885PLAU 3322/4885PLG 3328/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.