Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR5A | P47898 | 4/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | HPGD | P15428 | 1/20 | 0.34 |
| ▸ | CFB | P00751 | 3/20 | 0.33 |
| ▸ | SCN9A | Q15858 | 2/20 | 0.33 |
| ▸ | F7 | P08709 | 1/20 | 0.33 |
| ▸ | PLAU | P00749 | 1/20 | 0.32 |
| ▸ | DUSP3 | P51452 | 1/20 | 0.32 |
| ▸ | CASP3 | P42574 | 1/20 | 0.32 |
| ▸ | CYP1A1 | P04798 | 1/20 | 0.32 |
| ▸ | CYP1B1 | Q16678 | 1/20 | 0.32 |
| ▸ | EGLN1 | Q9GZT9 | 2/20 | 0.32 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.31 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.31 |
| ▸ | CA12 | O43570 | 1/20 | 0.31 |
| ▸ | CA1 | P00915 | 1/20 | 0.31 |
| ▸ | CA2 | P00918 | 1/20 | 0.31 |
| ▸ | CA9 | Q16790 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9909247 | 0.91 | HTR5A (0.56) | HTR5AKDM4EALDH1A1HPGDCFB | |
| SCHEMBL9909257 | 0.84 | SLC22A12 (0.42) | HTR5AKDM4EALDH1A1HPGDCFB | |
| SCHEMBL9925238 | 0.84 | HTR5A (0.49) | HTR5ASCN9APLAUEGLN1 | |
| SCHEMBL12875034 | 0.81 | SCN9A (0.43) | SCN9APLAUEGLN1 | |
| SCHEMBL9909238 | 0.80 | ALDH1A1 (0.47) | KDM4EALDH1A1HPGD | |
| SCHEMBL12875047 | 0.78 | HTR5A (0.63) | HTR5AKDM4ECASP3 | |
| SCHEMBL9909242 | 0.74 | HTR5A (0.59) | HTR5ASCN9APLAU | |
| SCHEMBL12875065 | 0.73 | HTR5A (0.52) | HTR5ASCN9APLAU | |
| SCHEMBL10064021 | 0.72 | HTR5A (0.39) | HTR5APLAU | |
| SCHEMBL9907622 | 0.72 | TDP1 (0.45) | HTR5AKDM4EALDH1A1HPGDCASP3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2463276-A1 | NITROGENOUS-RING ACYLGUANIDINE DERIVATIVE | Astellas Pharma Inc. (JP) | 2012-06-13 | — | — | EP | disclosed |
| WO-2011016504-A1 | NITROGENOUS-RING ACYLGUANIDINE DERIVATIVE | アステラス製薬株式会社 (JP) | 2011-02-10 | — | — | WO | disclosed |