Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE10A | Q9Y233 | 11/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
| ▸ | HTT | P42858 | 2/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1458472 | 0.83 | HTT (0.52) | PDE10ASMN1; SMN2KDM4EALDH1A1MAPT | |
| SCHEMBL16211920 | 0.82 | PDE10A (0.50) | PDE10ASMN1; SMN2KDM4EALDH1A1MAPT | |
| SCHEMBL11890121 | 0.79 | PDE10A (0.51) | PDE10AHTT | |
| SCHEMBL9926248 | 0.75 | KDM4E (0.38) | PDE10ASMN1; SMN2KDM4EALDH1A1KMT2A | |
| SCHEMBL7514360 | 0.73 | SMN1; SMN2 (0.50) | PDE10ASMN1; SMN2KDM4EALDH1A1MAPT | |
| SCHEMBL15767454 | 0.72 | GAA (0.43) | PDE10ASMN1; SMN2ALDH1A1HTTKMT2A | |
| SCHEMBL9926264 | 0.72 | PDE10A (0.39) | PDE10AALDH1A1MAPT | |
| SCHEMBL28844277 | 0.71 | CYP3A4 (0.47) | PDE10AALDH1A1HTT | |
| SCHEMBL1458202 | 0.70 | PDE10A (0.50) | PDE10A | |
| SCHEMBL9106126 | 0.70 | POLB (0.49) | PDE10A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012076430-A1 | TRIAZOLOPYRIDINE COMPOUNDS | F. HOFFMANN-LA ROCHE AG (CH) | 2012-06-14 | — | — | WO | disclosed |