Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE10A | Q9Y233 | 14/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | SPR | P35270 | 1/20 | 0.34 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.31 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.31 |
| ▸ | MAPT | P10636 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9926248 | 0.82 | KDM4E (0.38) | PDE10ALMNACYP1A2CYP2C19ALDH1A1 | |
| SCHEMBL1458251 | 0.80 | PDE10A (0.44) | PDE10ALMNASPR | |
| SCHEMBL6917068 | 0.79 | MAPT (0.44) | PDE10ALMNASPRALDH1A1MAPT | |
| SCHEMBL16260492 | 0.75 | SMN1; SMN2 (0.39) | PDE10ALMNASPRALDH1A1 | |
| SCHEMBL13772267 | 0.73 | SPR (0.38) | PDE10ALMNASPRALDH1A1MAPT | |
| SCHEMBL9926277 | 0.72 | PDE10A (0.49) | PDE10AALDH1A1MAPT | |
| SCHEMBL13772265 | 0.69 | HSD11B1 (0.42) | PDE10ALMNASPRALDH1A1MAPT | |
| SCHEMBL2373379 | 0.69 | PDE10A (0.49) | PDE10ALMNASPR | |
| SCHEMBL15182833 | 0.69 | PDE10A (0.36) | PDE10ALMNACYP1A2CYP2C19 | |
| SCHEMBL12261124 | 0.68 | LMNA (0.58) | LMNACYP1A2CYP2C19 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012076430-A1 | TRIAZOLOPYRIDINE COMPOUNDS | F. HOFFMANN-LA ROCHE AG (CH) | 2012-06-14 | — | — | WO | disclosed |