Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.67 |
| ▸ | SMN1; SMN2 | Q16637 | 6/20 | 0.67 |
| ▸ | HPGD | P15428 | 3/20 | 0.67 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.67 |
| ▸ | RAB9A | P51151 | 9/20 | 0.66 |
| ▸ | KDM4E | B2RXH2 | 8/20 | 0.66 |
| ▸ | NPC1 | O15118 | 5/20 | 0.66 |
| ▸ | GFER | P55789 | 2/20 | 0.59 |
| ▸ | TP53 | P04637 | 4/20 | 0.59 |
| ▸ | MAPT | P10636 | 3/20 | 0.59 |
| ▸ | POLB | P06746 | 3/20 | 0.56 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.55 |
| ▸ | LMNA | P02545 | 4/20 | 0.54 |
| ▸ | PKM | P14618 | 1/20 | 0.54 |
| ▸ | THRB | P10828 | 2/20 | 0.51 |
| ▸ | CASP3 | P42574 | 1/20 | 0.51 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2740002 | 0.92 | TP53 (0.70) | ALDH1A1SMN1; SMN2HPGDMAPK1RAB9A | |
| SCHEMBL2740004 | 0.90 | ALDH1A1 (0.80) | ALDH1A1SMN1; SMN2HPGDMAPK1RAB9A | |
| SCHEMBL2740003 | 0.80 | ALDH1A1 (0.74) | ALDH1A1SMN1; SMN2HPGDMAPK1RAB9A | |
| SCHEMBL4728109 | 0.80 | ALDH1A1 (1.00) | ALDH1A1SMN1; SMN2HPGDMAPK1RAB9A | |
| SCHEMBL12726152 | 0.80 | KDM4E (0.65) | ALDH1A1SMN1; SMN2HPGDMAPK1RAB9A | |
| SCHEMBL1494756 | 0.78 | RAB9A (0.79) | ALDH1A1SMN1; SMN2HPGDMAPK1RAB9A | |
| SCHEMBL12422039 | 0.78 | KDM4E (0.60) | ALDH1A1SMN1; SMN2HPGDMAPK1RAB9A | |
| SCHEMBL1494791 | 0.77 | GFER (0.79) | ALDH1A1SMN1; SMN2HPGDMAPK1RAB9A | |
| SCHEMBL12519402 | 0.77 | HTT (0.66) | ALDH1A1SMN1; SMN2HPGDMAPK1RAB9A | |
| SCHEMBL12519564 | 0.77 | MAPT (0.50) | ALDH1A1SMN1; SMN2MAPK1RAB9AKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1955077-B1 | MASS SPECTROMETRY ASSAYS FOR ACETYLTRANSFERASE/DEACETYLASE ACTIVITY | SIRTRIS PHARMACEUTICALS INC (US) | 2012-06-13 | — | — | EP | disclosed |