SCHEMBL9926362

SCHEMBL9926362

Cc1ccc(Oc2cncc(C(N)=O)c2)cc1

nearest known ligand 0.65

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
SIRT2 Q8IXJ6 7/20 0.65
SIRT3 Q9NTG7 7/20 0.65
SIRT1 Q96EB6 6/20 0.65
PARP10 Q53GL7 5/20 0.50
PARP15 Q460N3 3/20 0.50
PARP14 Q460N5 2/20 0.50
ALDH1A1 P00352 1/20 0.50
KMT2A Q03164 1/20 0.50
PARP16 Q8N5Y8 1/20 0.50
PARP11 Q9NR21 1/20 0.50
PARP4 Q9UKK3 1/20 0.50
XDH P47989 1/20 0.50
ICAM1 P05362 1/20 0.50
SELE P16581 1/20 0.50
VCAM1 P19320 1/20 0.50
CCNC P24863 1/20 0.50
CDK8 P49336 1/20 0.50
CHEK2 O96017 1/20 0.48
CYP11B1 P15538 1/20 0.48
CYP11B2 P19099 1/20 0.48

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL28281436 0.86 SIRT2 (0.76) SIRT2SIRT3SIRT1PARP10PARP15
SCHEMBL20176626 0.84 SIRT2 (0.65) SIRT2SIRT3SIRT1PARP10PARP15
SCHEMBL6014132 0.82 MMP13 (0.67) SIRT2SIRT3SIRT1XDHMMP13
SCHEMBL15314416 0.79 SIRT2 (0.57) SIRT2SIRT3SIRT1PARP10PARP15
SCHEMBL3013339 0.79 PARP10 (0.79) PARP10PARP15PARP14ALDH1A1KMT2A
SCHEMBL24592196 0.79 PARP10 (0.79) PARP10PARP15PARP14ALDH1A1KMT2A
SCHEMBL3698084 0.78 SIRT2 (0.54) SIRT2SIRT3SIRT1
SCHEMBL6014722 0.78 PARP10 (0.78) PARP10PARP15PARP14ALDH1A1KMT2A
SCHEMBL13932809 0.76 MMP13 (0.71) SIRT2SIRT3SIRT1ALDH1A1XDH
SCHEMBL10163507 0.76 MMP13 (0.56) SIRT2SIRT3SIRT1ALDH1A1XDH

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1636585-B2 DIARYL UREAS WITH KINASE INHIBITING ACTIVITY BAYER HEALTHCARE LLC (US) 2012-06-13 EP disclosed
EP-2298311-A1 w-Carboxy aryl substituted diphenyl ureas as p38 kinase inhibitors Bayer Healthcare Llc (US) 2011-03-23 EP disclosed
EP-1636585-B1 DIARYL UREAS WITH KINASE INHIBITING ACTIVITY BAYER PHARMACEUTICALS CORP (US) 2008-01-16 EP disclosed
WO-2007053574-A2 COMBINATIONS COMPRISING SORAFENIB AND INTERFERON FOR THE TREATMENT OF CANCER BAYER PHARMACEUTICALS CORPORATION (US) 2007-05-10 WO disclosed