Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIRT2 | Q8IXJ6 | 7/20 | 0.65 |
| ▸ | SIRT3 | Q9NTG7 | 7/20 | 0.65 |
| ▸ | SIRT1 | Q96EB6 | 6/20 | 0.65 |
| ▸ | PARP10 | Q53GL7 | 8/20 | 0.50 |
| ▸ | PARP15 | Q460N3 | 4/20 | 0.50 |
| ▸ | PARP14 | Q460N5 | 2/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.50 |
| ▸ | PARP16 | Q8N5Y8 | 1/20 | 0.50 |
| ▸ | PARP11 | Q9NR21 | 1/20 | 0.50 |
| ▸ | PARP4 | Q9UKK3 | 1/20 | 0.50 |
| ▸ | CDC7 | O00311 | 1/20 | 0.50 |
| ▸ | DYRK3 | O43781 | 1/20 | 0.50 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.50 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.50 |
| ▸ | ICAM1 | P05362 | 1/20 | 0.50 |
| ▸ | FYN | P06241 | 1/20 | 0.50 |
| ▸ | CDK1 | P06493 | 1/20 | 0.50 |
| ▸ | PIM1 | P11309 | 1/20 | 0.50 |
| ▸ | SELE | P16581 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28281436 | 0.86 | SIRT2 (0.76) | SIRT2SIRT3SIRT1PARP10PARP15 | |
| SCHEMBL9926362 | 0.84 | SIRT2 (0.65) | SIRT2SIRT3SIRT1PARP10PARP15 | |
| SCHEMBL20176625 | 0.82 | ATM (0.51) | SIRT2SIRT3SIRT1ALDH1A1KMT2A | |
| SCHEMBL15314416 | 0.79 | SIRT2 (0.57) | SIRT2SIRT3SIRT1PARP10PARP15 | |
| SCHEMBL3698084 | 0.76 | SIRT2 (0.54) | SIRT2SIRT3SIRT1ROCK1 | |
| SCHEMBL31137907 | 0.74 | POLB (0.67) | SIRT2SIRT3SIRT1ALDH1A1KMT2A | |
| SCHEMBL578591 | 0.74 | POLB (0.67) | SIRT2SIRT3SIRT1ALDH1A1KMT2A | |
| SCHEMBL28068268 | 0.73 | PARP15 (0.55) | SIRT2SIRT3SIRT1PARP10PARP15 | |
| SCHEMBL9448469 | 0.73 | MKNK1 (0.66) | SIRT2SIRT3SIRT1PARP10PARP4 | |
| SCHEMBL28347899 | 0.73 | SIRT2 (0.54) | SIRT2SIRT3SIRT1KMT2AMAP4K4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2018092047-A1 | INHIBITORS OF BRUTON'S TYROSINE KINASE | JOINT STOCK COMPANY "BIOCAD" (RU) | 2018-05-24 | — | — | WO | disclosed |