Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDPK1 | O15530 | 2/20 | 0.58 |
| ▸ | PLK4 | O00444 | 3/20 | 0.45 |
| ▸ | PLK1 | P53350 | 3/20 | 0.45 |
| ▸ | TGM2 | P21980 | 6/20 | 0.43 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.40 |
| ▸ | MAP3K7 | O43318 | 1/20 | 0.39 |
| ▸ | TAB1 | Q15750 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.39 |
| ▸ | MAPT | P10636 | 2/20 | 0.39 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | PKM | P14618 | 1/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.39 |
| ▸ | RET | P07949 | 2/20 | 0.39 |
| ▸ | FLT3 | P36888 | 1/20 | 0.39 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.39 |
| ▸ | CES1 | P23141 | 1/20 | 0.39 |
| ▸ | KDR | P35968 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2331366 | 0.78 | PDPK1 (0.54) | PDPK1PLK4PLK1TGM2ALDH1A1 | |
| SCHEMBL5728638 | 0.74 | PDPK1 (1.00) | PDPK1RETFLT3PDGFRBKDR | |
| SCHEMBL27553562 | 0.74 | TGM2 (0.73) | PDPK1TGM2MAP3K7TAB1 | |
| SCHEMBL5728634 | 0.74 | PDPK1 (1.00) | PDPK1RETFLT3PDGFRBKDR | |
| SCHEMBL6917819 | 0.72 | PDPK1 (0.49) | PDPK1PLK4PLK1TGM2ALDH1A1 | |
| SCHEMBL21837129 | 0.72 | EPHX2 (0.65) | PDPK1PLK4PLK1TGM2EPHX2 | |
| SCHEMBL4861892 | 0.64 | KDR (0.60) | PDPK1TGM2EPHX2ALDH1A1MAPT | |
| SCHEMBL4996116 | 0.64 | TGM2 (0.48) | PDPK1TGM2ALDH1A1MAPTNPSR1 | |
| SCHEMBL4996113 | 0.64 | TGM2 (0.48) | PDPK1TGM2ALDH1A1MAPTNPSR1 | |
| SCHEMBL4861881 | 0.64 | KDR (0.60) | PDPK1TGM2EPHX2ALDH1A1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012078519-A2 | 3-ACYLIDENE-2-OXOINDOLE DERIVATIVES FOR INHIBITION OF TRANSGLUTAMINASE 2 | NUMERATE, INC. (US) | 2012-06-14 | — | — | WO | disclosed |