Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.66 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.66 |
| ▸ | POLB | P06746 | 1/20 | 0.66 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.66 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.50 |
| ▸ | LMNA | P02545 | 1/20 | 0.50 |
| ▸ | CHKA | P35790 | 1/20 | 0.49 |
| ▸ | CYP2A13 | Q16696 | 1/20 | 0.47 |
| ▸ | MC4R | P32245 | 1/20 | 0.47 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.47 |
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.47 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.47 |
| ▸ | HTR6 | P50406 | 2/20 | 0.46 |
| ▸ | HTR1A | P08908 | 1/20 | 0.46 |
| ▸ | HTR7 | P34969 | 1/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.46 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.46 |
| ▸ | NR1H2 | P55055 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18753850 | 0.87 | ALDH1A1 (0.61) | ALDH1A1KDM4EPOLBTDP1SIGMAR1 | |
| SCHEMBL2656580 | 0.85 | KDM4E (0.88) | ALDH1A1KDM4EPOLBTDP1SIGMAR1 | |
| SCHEMBL15417767 | 0.83 | TDP1 (0.56) | ALDH1A1POLBTDP1LMNASMN1; SMN2 | |
| SCHEMBL18753928 | 0.82 | KDM4E (0.64) | ALDH1A1KDM4EPOLBTDP1SIGMAR1 | |
| SCHEMBL10520780 | 0.82 | CYP2A13 (0.46) | ALDH1A1KDM4EPOLBTDP1SIGMAR1 | |
| SCHEMBL12120512 | 0.82 | ALDH1A1 (0.64) | ALDH1A1KDM4EPOLBTDP1SIGMAR1 | |
| SCHEMBL4243681 | 0.82 | CYP2A13 (0.71) | KDM4ETDP1LMNACYP2A13NPSR1 | |
| SCHEMBL4758225 | 0.80 | NR1H2 (0.64) | ALDH1A1KDM4EPOLBTDP1LMNA | |
| SCHEMBL21551100 | 0.80 | KDM4E (0.49) | ALDH1A1KDM4EPOLBTDP1HTR6 | |
| SCHEMBL22422494 | 0.80 | ALDH1A1 (0.50) | ALDH1A1KDM4EPOLBTDP1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20120149661-A1 | TETRA-SUBSTITUTED HETEROARYL COMPOUNDS AND THEIR USE AS MDM2 AND/OR MDM4 MODULATORS | NOVARTIS AG (CH) | 2012-06-14 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120149661-A1 | TETRA-SUBSTITUTED HETEROARYL COMPOUNDS AND THEIR USE AS MDM2 AND/OR MDM4 MODULATORS | MDM4, MDM2, TP53 | ALDH1A1 4361/4885KDM4E 983/4885POLB 2312/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.