Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.88 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.88 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.88 |
| ▸ | POLB | P06746 | 2/20 | 0.88 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.69 |
| ▸ | CYP2A13 | Q16696 | 1/20 | 0.66 |
| ▸ | CHKA | P35790 | 1/20 | 0.61 |
| ▸ | MAPT | P10636 | 2/20 | 0.57 |
| ▸ | DDR1 | Q08345 | 1/20 | 0.52 |
| ▸ | MEN1 | O00255 | 1/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.51 |
| ▸ | RORC | P51449 | 1/20 | 0.51 |
| ▸ | HTR6 | P50406 | 1/20 | 0.51 |
| ▸ | TSHR | P16473 | 1/20 | 0.50 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17918745 | 0.85 | ALDH1A1 (0.66) | KDM4EALDH1A1TDP1POLBSIGMAR1 | |
| SCHEMBL28156384 | 0.85 | SIGMAR1 (0.67) | KDM4EALDH1A1TDP1POLBSIGMAR1 | |
| SCHEMBL9926517 | 0.85 | ALDH1A1 (0.66) | KDM4EALDH1A1TDP1POLBSIGMAR1 | |
| SCHEMBL24508364 | 0.84 | KDM4E (0.73) | KDM4EALDH1A1TDP1POLBSIGMAR1 | |
| SCHEMBL12120512 | 0.83 | ALDH1A1 (0.64) | KDM4EALDH1A1TDP1POLBSIGMAR1 | |
| SCHEMBL29672011 | 0.83 | ALDH1A1 (0.64) | KDM4EALDH1A1TDP1POLBSIGMAR1 | |
| SCHEMBL29694119 | 0.83 | ALDH1A1 (0.64) | KDM4EALDH1A1TDP1POLBSIGMAR1 | |
| SCHEMBL591420 | 0.83 | ALDH1A1 (0.64) | KDM4EALDH1A1TDP1POLBSIGMAR1 | |
| SCHEMBL23775596 | 0.83 | SIGMAR1 (0.65) | KDM4EALDH1A1TDP1POLBSIGMAR1 | |
| SCHEMBL18753928 | 0.83 | KDM4E (0.64) | KDM4EALDH1A1TDP1POLBSIGMAR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7196106-B2 | Cyanothiophene derivatives, compositions containing such compounds and methods of use | MERCK & CO., INC (US) | 2007-03-27 | — | — | US | disclosed |
| US-7196106-B2 | Cyanothiophene derivatives, compositions containing such compounds and methods of use | MERCK & CO., INC (US) | 2007-03-27 | — | — | US | disclosed |
| US-20040097552-A1 | Cyanothiophene derivatives, compositions containing such compounds and methods of use | MERCK SHARP & DOHME CORP. | 2004-05-20 | — | — | US | disclosed |
| US-20040097552-A1 | Cyanothiophene derivatives, compositions containing such compounds and methods of use | MERCK SHARP & DOHME CORP. | 2004-05-20 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040097552-A1 | Cyanothiophene derivatives, compositions containing such compounds and methods of use | GLP1R, GPR119, GCGR | KDM4E 3615/4885ALDH1A1 2652/4885TDP1 3851/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.