Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAP4K3 | Q8IVH8 | 5/20 | 0.43 |
| ▸ | MET | P08581 | 7/20 | 0.41 |
| ▸ | ALK | Q9UM73 | 1/20 | 0.41 |
| ▸ | AXL | P30530 | 4/20 | 0.41 |
| ▸ | MERTK | Q12866 | 4/20 | 0.41 |
| ▸ | JAK2 | O60674 | 2/20 | 0.40 |
| ▸ | GRK5 | P34947 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2680817 | 0.87 | MET (0.49) | MAP4K3MET | |
| SCHEMBL4089510 | 0.80 | MET (0.55) | MAP4K3METAXLMERTKJAK2 | |
| SCHEMBL14764140 | 0.78 | KDM5A (0.41) | JAK2 | |
| SCHEMBL16390864 | 0.77 | EGFR (0.51) | METGRK5 | |
| SCHEMBL18616304 | 0.77 | MAP4K3 (0.60) | MAP4K3METALKJAK2GRK5 | |
| SCHEMBL17310200 | 0.74 | MET (0.53) | MAP4K3METALK | |
| SCHEMBL2479647 | 0.74 | MAP3K7 (0.45) | MAP4K3METALKAXLMERTK | |
| SCHEMBL2330627 | 0.74 | MET (0.51) | MAP4K3MET | |
| SCHEMBL20067677 | 0.73 | MAP4K3 (0.53) | MAP4K3METAXLMERTK | |
| SCHEMBL2385504 | 0.72 | MET (0.53) | MAP4K3METAXLMERTK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2454253-B1 | AMINOPYRIDINE DERIVATIVES FOR TREATING TUMORS AND INFLAMMATORY DISEASES | MERCK PATENT GMBH (DE) | 2015-01-21 | — | — | EP | disclosed |
| EP-2454253-A1 | AMINOPYRIDINE DERIVATIVES FOR TREATING TUMORS AND INFLAMMATORY DISEASES | Merck Patent GmbH (DE) | 2012-05-23 | — | — | EP | disclosed |
| WO-2011006567-A1 | AMINOPYRIDINE DERIVATIVES FOR TREATING TUMORS AND INFLAMMATORY DISEASES | MERCK PATENT GMBH (DE) | 2011-01-20 | — | — | WO | disclosed |