Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAP3K7 | O43318 | 2/20 | 0.45 |
| ▸ | TAB1 | Q15750 | 2/20 | 0.45 |
| ▸ | MET | P08581 | 2/20 | 0.41 |
| ▸ | PAK1 | Q13153 | 5/20 | 0.40 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.40 |
| ▸ | FGFR2 | P21802 | 1/20 | 0.40 |
| ▸ | FGFR4 | P22455 | 1/20 | 0.40 |
| ▸ | FGFR3 | P22607 | 1/20 | 0.40 |
| ▸ | KDR | P35968 | 1/20 | 0.40 |
| ▸ | FLT3 | P36888 | 1/20 | 0.40 |
| ▸ | AXL | P30530 | 3/20 | 0.39 |
| ▸ | MERTK | Q12866 | 3/20 | 0.39 |
| ▸ | MAP4K3 | Q8IVH8 | 2/20 | 0.38 |
| ▸ | PKN1 | Q16512 | 1/20 | 0.38 |
| ▸ | IRAK1 | P51617 | 2/20 | 0.37 |
| ▸ | ALK | Q9UM73 | 1/20 | 0.37 |
| ▸ | RET | P07949 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1321592 | 0.88 | MET (0.52) | MAP3K7TAB1METPAK1FGFR1 | |
| SCHEMBL1581181 | 0.84 | MET (0.47) | METFGFR1FGFR2FGFR3 | |
| SCHEMBL2474231 | 0.82 | MET (0.44) | METPAK1AXLMERTKRET | |
| SCHEMBL2481596 | 0.82 | MET (0.49) | MET | |
| SCHEMBL27859570 | 0.81 | MAP3K7 (0.52) | MAP3K7TAB1METPAK1AXL | |
| SCHEMBL12547684 | 0.80 | MET (0.52) | MAP3K7TAB1METFGFR1FGFR2 | |
| SCHEMBL3631784 | 0.79 | GPR119 (0.38) | ALK | |
| SCHEMBL20280701 | 0.76 | MET (0.52) | METFGFR1FGFR2FGFR4FGFR3 | |
| SCHEMBL15416081 | 0.76 | MET (0.54) | METFGFR1FGFR2FGFR4FGFR3 | |
| SCHEMBL15431560 | 0.76 | GPR119 (0.55) | METFGFR1FGFR2FGFR4FGFR3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2181111-B1 | THIADIAZINONE DERIVATIVES | MERCK PATENT GMBH (DE) | 2013-06-26 | — | — | EP | disclosed |
| EP-2373644-B1 | PYRIDAZINONE DERIVATIVES | MERCK PATENT GMBH (DE) | 2012-10-24 | — | — | EP | disclosed |
| EP-2373644-A1 | PYRIDAZINONE DERIVATIVES | Merck Patent GmbH (DE) | 2011-10-12 | — | — | EP | disclosed |
| WO-2010078910-A1 | PYRIDAZINONE DERIVATIVES | MERCK PATENT GMBH (DE) | 2010-07-15 | — | — | WO | disclosed |
| EP-2181111-A1 | THIADIAZINONE DERIVATIVES | Merck Patent GmbH (DE) | 2010-05-05 | — | — | EP | disclosed |
| WO-2009030333-A1 | THIADIAZINONE DERIVATIVES | MERCK PATENT GMBH (DE) | 2009-03-12 | — | — | WO | disclosed |