Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNA5 | P22460 | 3/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.43 |
| ▸ | POLB | P06746 | 3/20 | 0.43 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.42 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.41 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.41 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.41 |
| ▸ | P2RX7 | Q99572 | 2/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | RAB9A | P51151 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | THRB | P10828 | 1/20 | 0.40 |
| ▸ | TSHR | P16473 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1242284 | 0.85 | KCNA5 (0.47) | KCNA5ALDH1A1KDM4EHSD17B10POLB | |
| SCHEMBL1240803 | 0.85 | KCNA5 (0.52) | KCNA5ALDH1A1KDM4EHSD17B10POLB | |
| SCHEMBL1243292 | 0.83 | POLB (0.54) | KCNA5ALDH1A1KDM4EHSD17B10POLB | |
| SCHEMBL1243207 | 0.83 | POLB (0.50) | KCNA5ALDH1A1KDM4EHSD17B10POLB | |
| SCHEMBL1242039 | 0.80 | KCNA5 (0.45) | KCNA5ALDH1A1KDM4EHSD17B10POLB | |
| SCHEMBL1243334 | 0.80 | KCNA5 (0.45) | KCNA5ALDH1A1KDM4EHSD17B10POLB | |
| SCHEMBL1242037 | 0.80 | KCNA5 (0.45) | KCNA5ALDH1A1KDM4EHSD17B10POLB | |
| SCHEMBL1242829 | 0.80 | P2RX7 (0.46) | KCNA5ALDH1A1KDM4EHSD17B10POLB | |
| SCHEMBL1242226 | 0.79 | KCNA5 (0.45) | KCNA5ALDH1A1KDM4EHSD17B10POLB | |
| SCHEMBL1243271 | 0.79 | ALDH1A1 (0.47) | KCNA5ALDH1A1KDM4EHSD17B10POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1781635-B1 | POTASSIUM CHANNEL INHIBITORS | MERCK SHARP & DOHME (US) | 2012-06-13 | — | — | EP | disclosed |