Known targets — ChEMBL curated mechanism
ADORA1ADORA2AADORA2BADORA3GNRHRMPLPDE3APDE3BPDE4APDE4BPDE4CPDE4DPPARASLC5A2
The experimentally established mechanism targets of Choline. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 3/20 | 0.71 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.71 |
| ▸ | LMNA | P02545 | 2/20 | 0.71 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.71 |
| ▸ | SLC5A7 | Q9GZV3 | 1/20 | 0.71 |
| ▸ | CHRM5 | P08912 | 2/20 | 0.40 |
| ▸ | CHRM1 | P11229 | 2/20 | 0.40 |
| ▸ | CHRM3 | P20309 | 2/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.40 |
| ▸ | PGR | P06401 | 1/20 | 0.40 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.40 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.40 |
| ▸ | HTR1A | P08908 | 1/20 | 0.40 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.40 |
| ▸ | TBXA2R | P21731 | 1/20 | 0.40 |
| ▸ | CHRNB4 | P30926 | 1/20 | 0.40 |
| ▸ | CHRNA3 | P32297 | 1/20 | 0.40 |
| ▸ | CHRNA7 | P36544 | 1/20 | 0.40 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.40 |
| ▸ | CHRNA10 | Q9GZZ6 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Choline SCHEMBL29118960 | 0.97 | MEN1 (0.77) | MEN1KMT2ALMNACYP3A4SLC5A7 | |
| Choline SCHEMBL21800980 | 0.97 | CYP3A4 (0.77) | MEN1KMT2ALMNACYP3A4SLC5A7 | |
| Choline SCHEMBL2469440 | 0.91 | MEN1 (0.67) | MEN1KMT2ALMNACYP3A4SLC5A7 | |
| Choline SCHEMBL8893408 | 0.88 | MEN1 (0.63) | MEN1KMT2ALMNACYP3A4SLC5A7 | |
| Choline SCHEMBL338525 | 0.88 | MEN1 (0.63) | MEN1KMT2ALMNACYP3A4SLC5A7 | |
| Choline SCHEMBL3785871 | 0.87 | — | — | |
| Choline SCHEMBL5586408 | 0.87 | — | — | |
| Choline SCHEMBL14330721 | 0.87 | — | — | |
| Choline SCHEMBL17629823 | 0.87 | MEN1 (0.92) | MEN1KMT2ALMNACYP3A4SLC5A7 | |
| Choline SCHEMBL300867 | 0.87 | MEN1 (0.92) | MEN1KMT2ALMNACYP3A4SLC5A7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 111 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2024103392-A1 | METHOD FOR PREPARING BIOLOGICAL VALVE MATERIAL BY COPOLYMERIZATION AND CROSSLINKING, BIOLOGICAL VALVE MATERIAL, AND USE | 四川大学 | 2024-05-23 | — | — | WO | claimed |
| WO-2023088330-A1 | BIOLOGICAL VALVE MATERIAL, AND PREPARATION METHOD THEREFOR AND USE THEREOF | 四川大学 | 2023-05-25 | — | — | WO | claimed |
| CN-113265037-B | Polyisocyanate composition and preparation method and application thereof | 万华化学（宁波）有限公司 | 2023-03-24 | — | — | CN | claimed |
| CN-112851502-B | Method for catalyzing waste PET polyester to carry out methanol alcoholysis by using choline and terephthalic acid non-metallic ionic liquid | 中国科学院过程工程研究所 | 2022-12-16 | — | — | CN | claimed |
| WO-2022241616-A1 | POLYISOCYANATE COMPOSITION, PREPARATION METHOD THEREFOR AND APPLICATION THEREOF | 万华化学（宁波）有限公司 | 2022-11-24 | — | — | WO | claimed |
| CN-113698572-A | Polyisocyanate composition, preparation method and application | 万华化学（宁波）有限公司 | 2021-11-26 | — | — | CN | claimed |
| CN-113265037-A | Polyisocyanate composition and preparation method and application thereof | 万华化学（宁波）有限公司 | 2021-08-17 | — | — | CN | claimed |
| CN-112851502-A | Method for catalyzing waste PET polyester to carry out methanol alcoholysis by using choline and terephthalic acid non-metallic ionic liquid | 中国科学院过程工程研究所 | 2021-05-28 | — | — | CN | claimed |
| CN-109757485-A | A kind of carboxylic acid cholinomimetic solid pharmaceutical preparation and preparation method thereof | 山东润博生物科技有限公司 | 2019-05-17 | — | — | CN | claimed |
| CN-105801874-B | Cyclodextrin-polyethylene glycol self assembly hyperbranched poly acrylamide copolymer oil displacement agent and preparation method thereof | 中国海洋石油集团有限公司 | 2018-08-07 | — | — | CN | claimed |
| CN-107920504-A | For the choline salt of water adjusting and without ammonium adjuvant and agriculture preparation | 罗地亚经营管理公司 | 2018-04-17 | — | — | CN | claimed |
| CN-105924580-A | Fluorine-containing water-soluble hyperbranched multi-arm polyacrylamide polymer | 中国海洋石油总公司 | 2016-09-07 | — | — | CN | claimed |
| CN-105884980-A | Fluorine-containing hyperbranched multi-armed polyacrylamides polymer | 中国海洋石油总公司 | 2016-08-24 | — | — | CN | claimed |
| CN-105801874-A | Cyclodextrin-polyethylene glycol self-assembly hyperbranched polyacrylamide polymeric oil-displacing agent and preparation method thereof | 中国海洋石油总公司 | 2016-07-27 | — | — | CN | claimed |
| CN-104877079-A | Water-soluble hyperbranched multi-arm polyacrylamide polymer and preparation method thereof | CHINA NAT OFFSHORE OIL CORP | 2015-09-02 | — | — | CN | claimed |
| CN-104844766-A | Hyperbranched multi-arm polyacrylamide polymer and preparation method thereof | CHINA NAT OFFSHORE OIL CORP | 2015-08-19 | — | — | CN | claimed |
| CN-104402742-A | Poly-quaternary ammonium salt-typed monomer (methyl) acrylyloxyethyl trimethyl ammonium chloride and synthetic method | UNIV SOUTHEAST | 2015-03-11 | — | — | CN | claimed |
| CN-104004502-A | Phosphite choline ester quaternary ammonium salt clay stabilizer and preparation method thereof | UNIV SOUTHEAST | 2014-08-27 | — | — | CN | claimed |
| US-6462005-B1 | AQUEOUS SOLUTION CONTAINING A QUARTERNARY AMMONIUM SALT, A FLUORO COMPOUND AND OPTIONALLY AN ORGANIC SOLVENT; PROTECTING DEPOSITION FILM TO BE REMOVED; NO CORROSION OF CONDUCTIVE LAYER BEING DECONTAMINATED | TEXAS INSTRUMENTS INCORPORATED | 2002-10-08 | — | — | US | claimed |
| US-5972862-A | COMPRISING A FLUORINE-CONTAINING COMPOUND, A WATER-SOLUBLE OR WATER-MISCIBLE ORGANIC SOLVENT, AN ORGANIC ACID, AND A QUATERNARY AMMONIUM SALT | MITSUBISHI GAS CHEMICAL (JP) | 1999-10-26 | — | — | US | claimed |