Known targets — ChEMBL curated mechanism
ADORA1ADORA2AADORA2BADORA3GNRHRMPLPDE3APDE3BPDE4APDE4BPDE4CPDE4DPPARASLC5A2
The experimentally established mechanism targets of Choline. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP3A4 | P08684 | 1/20 | 0.77 |
| ▸ | SLC5A7 | Q9GZV3 | 1/20 | 0.77 |
| ▸ | MEN1 | O00255 | 1/20 | 0.67 |
| ▸ | LMNA | P02545 | 1/20 | 0.67 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.67 |
| ▸ | CHRM5 | P08912 | 3/20 | 0.42 |
| ▸ | CHRM1 | P11229 | 3/20 | 0.42 |
| ▸ | CHRM3 | P20309 | 3/20 | 0.42 |
| ▸ | BLM | P54132 | 3/20 | 0.41 |
| ▸ | CHRM2 | P08172 | 2/20 | 0.39 |
| ▸ | CHRM4 | P08173 | 2/20 | 0.39 |
| ▸ | PGR | P06401 | 1/20 | 0.39 |
| ▸ | HTR1A | P08908 | 1/20 | 0.39 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.39 |
| ▸ | TBXA2R | P21731 | 1/20 | 0.39 |
| ▸ | CHRNB4 | P30926 | 1/20 | 0.39 |
| ▸ | CHRNA3 | P32297 | 1/20 | 0.39 |
| ▸ | CHRNA7 | P36544 | 1/20 | 0.39 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Choline SCHEMBL992915 | 0.97 | MEN1 (0.71) | CYP3A4SLC5A7MEN1LMNAKMT2A | |
| Choline SCHEMBL29118960 | 0.94 | MEN1 (0.77) | CYP3A4SLC5A7MEN1LMNAKMT2A | |
| Choline SCHEMBL4199945 | 0.89 | CYP3A4 (0.68) | CYP3A4SLC5A7MEN1LMNAKMT2A | |
| Choline SCHEMBL2469440 | 0.88 | MEN1 (0.67) | CYP3A4SLC5A7MEN1LMNAKMT2A | |
| Choline SCHEMBL1330530 | 0.87 | — | — | |
| Choline SCHEMBL2459999 | 0.87 | CYP3A4 (1.00) | CYP3A4SLC5A7MEN1LMNAKMT2A | |
| Choline SCHEMBL1332010 | 0.87 | — | — | |
| Choline SCHEMBL14957 | 0.87 | — | — | |
| Choline SCHEMBL9391204 | 0.87 | CYP3A4 (1.00) | CYP3A4SLC5A7MEN1LMNAKMT2A | |
| Choline SCHEMBL30612764 | 0.87 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 32 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-114790253-B | Acylated chitin and preparation method and application thereof | 中科南京绿色制造产业创新研究院 | 2024-03-26 | — | — | CN | claimed |
| WO-2023170106-A1 | AN ELECTROCHEMICAL PROCESS FOR RECOVERING PLATINUM GROUP METALS (PGMs) FROM SOLID RESIDUES | FUNDACION TECNALIA RESEARCH & INNOVATION (ES) | 2023-09-14 | — | — | WO | claimed |
| CN-116716751-A | Method for extracting cotton stalk lignin by ultrasonic-assisted choline chloride-formic acid eutectic solvent | 徐媛媛 | 2023-09-08 | — | — | CN | claimed |
| CN-109180617-B | Two-phase biomass pretreatment co-production chemical method based on furfural compound extractant | 中国科学院广州能源研究所 | 2020-12-04 | — | — | CN | claimed |
| CN-111154549-A | Method for extracting rose essential oil from rose waste residue after extraction of essential oil | 河北科技大学 | 2020-05-15 | — | — | CN | claimed |
| CN-118126159-A | Green and efficient preparation method of swimming bladder collagen | 中国农业大学 | 2024-06-04 | — | — | CN | disclosed |
| CN-118029185-A | Method for preparing pricklyash seed cellulose by superfine grinding auxiliary eutectic solvent | 农业农村部规划设计研究院 | 2024-05-14 | — | — | CN | disclosed |
| CN-114790253-B | Acylated chitin and preparation method and application thereof | 中科南京绿色制造产业创新研究院 | 2024-03-26 | — | — | CN | disclosed |
| US-11845909-B2 | Method for the extraction of bio-oil from algal biomass | ENI S.P.A. (IT) | 2023-12-19 | — | — | US | disclosed |
| CN-117085658-A | Amphetamine adsorbent and application thereof | 西南政法大学 | 2023-11-21 | — | — | CN | disclosed |
| CN-115678036-B | Method for extracting light-colored lignin based on ternary eutectic solvent | 华南理工大学 | 2023-09-22 | — | — | CN | disclosed |
| CN-116751987-A | Method for recycling anode material of waste lithium ion battery | 北京车和家汽车科技有限公司 | 2023-09-15 | — | — | CN | disclosed |
| WO-2021036156-A1 | EUTECTIC SOLVENT AND APPLICATION THEREOF IN EXTRACTING LIGNIN | 齐鲁工业大学 | 2021-03-04 | — | — | WO | disclosed |
| CN-110540508-B | Eutectic solvent and application thereof in extracting lignin | 齐鲁工业大学 | 2021-01-01 | — | — | CN | disclosed |
| CN-109180617-B | Two-phase biomass pretreatment co-production chemical method based on furfural compound extractant | 中国科学院广州能源研究所 | 2020-12-04 | — | — | CN | disclosed |
| CN-111154549-A | Method for extracting rose essential oil from rose waste residue after extraction of essential oil | 河北科技大学 | 2020-05-15 | — | — | CN | disclosed |
| WO-2020053118-A1 | METHOD FOR THE EXTRACTION OF BIO-OIL FROM ALGAL BIOMASS | ENI S.P.A. (IT) | 2020-03-19 | — | — | WO | disclosed |
| CN-110540508-A | Eutectic solvent and application thereof in extracting lignin | UNIV QILU TECHNOLOGY | 2019-12-06 | — | — | CN | disclosed |
| CN-109180617-A | A kind of two-phase biomass pretreatment coproduction chemical processes based on Furnan products extractant | 中国科学院广州能源研究所 | 2019-01-11 | — | — | CN | disclosed |
| CN-102971451-B | catalyst mixture | 二氧化碳材料公司 | 2016-09-14 | — | — | CN | disclosed |