Known targets — ChEMBL curated mechanism
ADORA1ADORA2AADORA2BADORA3GNRHRMPLPDE3APDE3BPDE4APDE4BPDE4CPDE4DPPARASLC5A2
The experimentally established mechanism targets of Choline. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 1/20 | 0.63 |
| ▸ | LMNA | P02545 | 1/20 | 0.63 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.63 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.63 |
| ▸ | SLC5A7 | Q9GZV3 | 1/20 | 0.63 |
| ▸ | CHRM2 | P08172 | 7/20 | 0.40 |
| ▸ | CHRM1 | P11229 | 7/20 | 0.40 |
| ▸ | CHRM3 | P20309 | 7/20 | 0.40 |
| ▸ | GALR3 | O60755 | 1/20 | 0.37 |
| ▸ | TSHR | P16473 | 1/20 | 0.35 |
| ▸ | ACHE | P22303 | 1/20 | 0.33 |
| ▸ | BLM | P54132 | 1/20 | 0.33 |
| ▸ | BBOX1 | O75936 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Choline SCHEMBL993190 | 0.97 | MEN1 (0.60) | MEN1LMNAKMT2ACYP3A4SLC5A7 | |
| Choline SCHEMBL993189 | 0.97 | LMNA (0.60) | MEN1LMNAKMT2ACYP3A4SLC5A7 | |
| Choline SCHEMBL992915 | 0.88 | MEN1 (0.71) | MEN1LMNAKMT2ACYP3A4SLC5A7 | |
| Choline SCHEMBL29118960 | 0.86 | MEN1 (0.77) | MEN1LMNAKMT2ACYP3A4SLC5A7 | |
| Choline SCHEMBL21800980 | 0.86 | CYP3A4 (0.77) | MEN1LMNAKMT2ACYP3A4SLC5A7 | |
| Choline SCHEMBL2469440 | 0.86 | MEN1 (0.67) | MEN1LMNAKMT2ACYP3A4SLC5A7 | |
| Formic Acid SCHEMBL2185743 | 0.84 | MEN1 (0.43) | MEN1LMNAKMT2ACYP3A4SLC5A7 | |
| Formic Acid SCHEMBL28452505 | 0.84 | MEN1 (0.44) | MEN1LMNAKMT2ACYP3A4SLC5A7 | |
| Formic Acid SCHEMBL4634656 | 0.83 | MEN1 (0.41) | MEN1LMNAKMT2ACYP3A4SLC5A7 | |
| Choline SCHEMBL8893408 | 0.83 | MEN1 (0.63) | MEN1LMNAKMT2ACYP3A4SLC5A7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 176 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-120022522-A | Drug-loaded microneedle, drug-loaded microneedle patch and electrically-controlled drug release microneedle system | 成都邦迈医创科技有限公司 | 2025-05-23 | — | — | CN | claimed |
| CN-119798586-A | Preparation method of polyisocyanate composition | 万华化学集团股份有限公司 | 2025-04-11 | — | — | CN | claimed |
| CN-119285919-B | Flame-retardant functional degradation method of unsaturated polyester and application of product thereof | 中国科学技术大学 | 2025-03-11 | — | — | CN | claimed |
| CN-119285919-A | Flame-retardant functional degradation method of unsaturated polyester and application of product thereof | 中国科学技术大学 | 2025-01-10 | — | — | CN | claimed |
| CN-118165226-A | Preparation method of polyisocyanate composition | 万华化学（宁波）有限公司 | 2024-06-11 | — | — | CN | claimed |
| CN-118165221-A | Allophanate composition, polyisocyanate composition, and preparation methods and applications thereof | 万华化学（宁波）有限公司 | 2024-06-11 | — | — | CN | claimed |
| CN-113698572-B | Polyisocyanate composition, preparation method and application | 万华化学（宁波）有限公司 | 2023-12-19 | — | — | CN | claimed |
| CN-116854890-A | Preparation method of polyisocyanate composition | 万华化学集团股份有限公司 | 2023-10-10 | — | — | CN | claimed |
| CN-115246793-B | Preparation method of diisocyanate trimer, catalyst and preparation method thereof | 山东新和成精化科技有限公司 | 2023-07-07 | — | — | CN | claimed |
| CN-113265037-B | Polyisocyanate composition and preparation method and application thereof | 万华化学（宁波）有限公司 | 2023-03-24 | — | — | CN | claimed |
| CN-115246793-A | Preparation method of diisocyanate trimer, catalyst and preparation method thereof | 山东新和成精化科技有限公司 | 2022-10-28 | — | — | CN | claimed |
| CN-113698572-A | Polyisocyanate composition, preparation method and application | 万华化学（宁波）有限公司 | 2021-11-26 | — | — | CN | claimed |
| CN-113265037-A | Polyisocyanate composition and preparation method and application thereof | 万华化学（宁波）有限公司 | 2021-08-17 | — | — | CN | claimed |
| WO-2018141067-A9 | DECONSTRUCTION OF OILSAND MATERIALS USING IONIC LIQUIDS | UTI LIMITED PARTNERSHIP (CA) | 2018-08-30 | — | — | WO | claimed |
| WO-2018141067-A1 | DECONSTRUCTION OF OILSAND MATERIALS USING IONIC LIQUIDS | UTI LIMITED PARTNERSHIP (CA) | 2018-08-09 | — | — | WO | claimed |
| US-8187489-B1 | Biodegradable ionic liquids for aircraft deicing | THE UNITED STATES OF AMERICA AS REPRESENTED BY THE SECRETARY OF THE NAVY (US) | 2012-05-29 | — | — | US | claimed |
| US-6462005-B1 | AQUEOUS SOLUTION CONTAINING A QUARTERNARY AMMONIUM SALT, A FLUORO COMPOUND AND OPTIONALLY AN ORGANIC SOLVENT; PROTECTING DEPOSITION FILM TO BE REMOVED; NO CORROSION OF CONDUCTIVE LAYER BEING DECONTAMINATED | TEXAS INSTRUMENTS INCORPORATED | 2002-10-08 | — | — | US | claimed |
| US-5972862-A | COMPRISING A FLUORINE-CONTAINING COMPOUND, A WATER-SOLUBLE OR WATER-MISCIBLE ORGANIC SOLVENT, AN ORGANIC ACID, AND A QUATERNARY AMMONIUM SALT | MITSUBISHI GAS CHEMICAL (JP) | 1999-10-26 | — | — | US | claimed |
| EP-0501776-A1 | Stabilization of subterranean formations | HALLIBURTON COMPANY (US) | 1992-09-02 | — | — | EP | claimed |
| US-5097904-A | Flow control agents in enhanced oil recovery | HALLIBURTON COMPANY (US) | 1992-03-24 | — | — | US | claimed |