Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Bicarbonate. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.54 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.54 |
| ▸ | TSHR | P16473 | 1/20 | 0.54 |
| ▸ | CA2 | P00918 | 4/20 | 0.50 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.44 |
| ▸ | GABRB2 | P47870 | 1/20 | 0.44 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.41 |
| ▸ | CA12 | O43570 | 3/20 | 0.40 |
| ▸ | CA1 | P00915 | 3/20 | 0.40 |
| ▸ | CA7 | P43166 | 3/20 | 0.40 |
| ▸ | CA9 | Q16790 | 3/20 | 0.40 |
| ▸ | CA14 | Q9ULX7 | 3/20 | 0.40 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.40 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.40 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.40 |
| ▸ | THRB | P10828 | 1/20 | 0.39 |
| ▸ | GLRA3 | O75311 | 1/20 | 0.38 |
| ▸ | GLRB | P48167 | 1/20 | 0.38 |
| ▸ | TNFRSF1A | P19438 | 1/20 | 0.38 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Bicarbonate SCHEMBL28886280 | 1.00 | ALDH1A1 (0.54) | ALDH1A1TDP1TSHRCA2GABRA1 | |
| SCHEMBL144221 | 0.92 | ALDH1A1 (0.62) | ALDH1A1TDP1TSHRCA2GABRA1 | |
| SCHEMBL29395629 | 0.92 | ALDH1A1 (0.62) | ALDH1A1TDP1TSHRCA2GABRA1 | |
| SCHEMBL27551262 | 0.90 | ALDH1A1 (0.60) | ALDH1A1TDP1TSHRCA2GABRA1 | |
| SCHEMBL28429156 | 0.90 | ALDH1A1 (0.60) | ALDH1A1TDP1TSHRCA2GABRA1 | |
| Ammonia Solution, Strong SCHEMBL27531626 | 0.90 | ALDH1A1 (0.60) | ALDH1A1TDP1TSHRCA2GABRA1 | |
| SCHEMBL28886278 | 0.89 | CA2 (0.48) | ALDH1A1TDP1TSHRCA2GABRA1 | |
| Acrylic Acid SCHEMBL28531465 | 0.88 | TDP1 (0.46) | ALDH1A1TDP1TSHRCA2GABRA1 | |
| Phenol SCHEMBL27776986 | 0.86 | ALDH1A1 (0.57) | ALDH1A1TDP1TSHRCA2GABRA1 | |
| Propane SCHEMBL2457613 | 0.86 | ALDH1A1 (0.56) | ALDH1A1TDP1TSHRCA2GABRA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 59 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3887450-B1 | SULFUR-STABILIZED THERMOPLASTIC COMPOSITIONS, METHODS OF MAKING, AND ARTICLES FORMED THEREFROM | SHPP GLOBAL TECH BV (NL) | 2024-09-25 | — | — | EP | disclosed |
| US-11981277-B2 | Panel, integrated structure, and method | SABIC GLOBAL TECHNOLOGIES B.V. (NL) | 2024-05-14 | — | — | US | disclosed |
| US-11649322-B2 | Sulfur-stabilized copolycarbonates and articles formed therefrom | SHPP GLOBAL TECHNOLOGIES B.V. (NL) | 2023-05-16 | — | — | US | disclosed |
| US-11572468-B2 | Weatherable transparent high heat polycarbonate copolymer composition | SHPP GLOBAL TECHNOLOGIES B.V. (NL) | 2023-02-07 | — | — | US | disclosed |
| CN-113227251-B | Sulfur-stabilized thermoplastic compositions, methods of manufacture, and articles formed therefrom | 高新特殊工程塑料全球技术有限公司 | 2022-12-20 | — | — | CN | disclosed |
| CN-111100439-B | Weather resistant transparent high heat polycarbonate copolymer compositions | 高新特殊工程塑料全球技术有限公司 | 2022-12-02 | — | — | CN | disclosed |
| CN-111417668-B | Benzopyrrolo copolycarbonate optical articles, articles formed therefrom, and methods of making the same | 高新特殊工程塑料全球技术有限公司 | 2022-06-28 | — | — | CN | disclosed |
| CN-111253561-B | Copolycarbonates, methods of making, thermoplastic compositions comprising, and articles comprising the same | 高新特殊工程塑料全球技术有限公司 | 2022-05-27 | — | — | CN | disclosed |
| EP-3647368-B1 | WEATHERABLE TRANSPARENT HIGH HEAT POLYCARBONATE COPOLYMER COMPOSITION | SHPP GLOBAL TECH BV (NL) | 2021-12-01 | — | — | EP | disclosed |
| US-11174347-B2 | Phthalimidine copolycarbonate optical articles, articles formed therefrom, and methods of manufacture | SHPP GLOBAL TECHNOLOGIES B.V. (NL) | 2021-11-16 | — | — | US | disclosed |
| EP-3380553-A1 | COPOLYCARBONATE LENSES, METHODS OF MANUFACTURE, AND APPLICATIONS THEREOF | SABIC Global Technologies B.V. (NL) | 2018-10-03 | — | — | EP | disclosed |
| EP-3380563-A1 | COPOLYCARBONATE COMPOSITIONS HAVING ENHANCED OPTICAL PROPERTIES, ARTICLES FORMED THEREFROM, AND METHODS OF MANUFACTURE | SABIC Global Technologies B.V. (NL) | 2018-10-03 | — | — | EP | disclosed |
| US-20180105644-A1 | ULTRA-HIGH PURITY POLYCARBONATES HAVING GOOD INHERENT COLOR AND THERMAL RESISTANCE AND A DEVICE AND A METHOD FOR PRODUCING THE SAME | COVESTRO DEUTSCHLAND AG (DE) | 2018-04-19 | — | — | US | disclosed |
| WO-2018020425-A1 | POLYCARBONATE COMPOSITIONS HAVING ENHANCED OPTICAL PROPERTIES, ARTICLES FORMED THEREFROM, AND METHODS OF MANUFACTURE | SABIC GLOBAL TECHNOLOGIES B.V. (NL) | 2018-02-01 | — | — | WO | disclosed |
| WO-2017203497-A1 | COPOLYCARBONATE LENSES, METHODS OF MANUFACTURE, AND APPLICATIONS THEREOF | SABIC GLOBAL TECHNOLOGIES B.V. (NL) | 2017-11-30 | — | — | WO | disclosed |
| WO-2017203495-A1 | COPOLYCARBONATE LENSES, METHODS OF MANUFACTURE, AND APPLICATIONS THEREOF | SABIC GLOBAL TECHNOLOGIES B.V. (NL) | 2017-11-30 | — | — | WO | disclosed |
| WO-2017203493-A1 | COPOLYCARBONATE COMPOSITIONS HAVING ENHANCED OPTICAL PROPERTIES, ARTICLES FORMED THEREFROM, AND METHODS OF MANUFACTURE | SABIC GLOBAL TECHNOLOGIES B.V. (NL) | 2017-11-30 | — | — | WO | disclosed |
| WO-2017203496-A1 | HIGH HEAT COPOLYCARBONATE COMPOSITIONS HAVING ENHANCED OPTICAL PROPERTIES, ARTICLES FORMED THEREFROM, AND METHODS OF MANUFACTURE | SABIC GLOBAL TECHNOLOGIES B.V. (NL) | 2017-11-30 | — | — | WO | disclosed |
| US-9828464-B2 | Ultra-high purity polycarbonates having good inherent color and thermal resistance and a device and a method for producing the same | COVESTRO DEUTSCHLAND AG (DE) | 2017-11-28 | — | — | US | disclosed |
| US-20120157653-A1 | ULTRA-HIGH PURITY POLYCARBONATES HAVING GOOD INHERENT COLOR AND THERMAL RESISTANCE AND A DEVICE AND A METHOD FOR PRODUCING THE SAME | BAYER MATERIAL SECIENCE AG (DE) | 2012-06-21 | — | — | US | disclosed |