Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FGFR1 | P11362 | 2/20 | 0.51 |
| ▸ | SRC | P12931 | 2/20 | 0.51 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.47 |
| ▸ | ASIC3 | Q9UHC3 | 1/20 | 0.44 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.44 |
| ▸ | ALOX5AP | P20292 | 2/20 | 0.44 |
| ▸ | FEN1 | P39748 | 2/20 | 0.44 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.43 |
| ▸ | ADORA1 | P30542 | 2/20 | 0.43 |
| ▸ | CDK9 | P50750 | 2/20 | 0.41 |
| ▸ | ADORA2A | P29274 | 2/20 | 0.41 |
| ▸ | CSNK2A1 | P68400 | 1/20 | 0.41 |
| ▸ | USP7 | Q93009 | 1/20 | 0.40 |
| ▸ | TDO2 | P48775 | 1/20 | 0.40 |
| ▸ | SMARCA2 | P51531 | 1/20 | 0.40 |
| ▸ | SMARCA4 | P51532 | 1/20 | 0.40 |
| ▸ | PBRM1 | Q86U86 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1462979 | 0.82 | CYP2A6 (0.49) | CYP2A6ADORA2ATDO2 | |
| SCHEMBL9929901 | 0.81 | CDK9 (0.57) | FGFR1SRCMAP4K4ALOX5APFEN1 | |
| SCHEMBL30919693 | 0.80 | CYP2A6 (0.46) | FGFR1SRCMAP4K4CYP2A6ADORA1 | |
| SCHEMBL23277179 | 0.80 | CYP2A6 (0.46) | FGFR1SRCMAP4K4CYP2A6ADORA1 | |
| SCHEMBL4733656 | 0.77 | FGFR1 (0.51) | FGFR1SRCMAP4K4ASIC3PDPK1 | |
| SCHEMBL21290224 | 0.77 | MAP4K4 (0.47) | MAP4K4CYP2A6USP7TDO2SMARCA2 | |
| SCHEMBL21290181 | 0.77 | MAP4K4 (0.47) | MAP4K4CYP2A6ADORA1USP7 | |
| SCHEMBL21419499 | 0.77 | ALOX5AP (0.43) | FGFR1SRCPDPK1ALOX5APFEN1 | |
| SCHEMBL21223874 | 0.74 | FGFR1 (0.49) | FGFR1SRCMAP4K4ASIC3PDPK1 | |
| SCHEMBL9930222 | 0.74 | CNR2 (0.47) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20120157433-A1 | Heteroaryl Compounds as Kinase Inhibitors | PFISTER KEITH B (US) | 2012-06-21 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120157433-A1 | Heteroaryl Compounds as Kinase Inhibitors | CDK2, CDK1, CDK6 | FGFR1 464/4885SRC 334/4885MAP4K4 86/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.