Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CDK9 | P50750 | 2/20 | 0.57 |
| ▸ | CCNT1 | O60563 | 2/20 | 0.52 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.43 |
| ▸ | ALOX5AP | P20292 | 1/20 | 0.42 |
| ▸ | FEN1 | P39748 | 1/20 | 0.42 |
| ▸ | CHEK2 | O96017 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | MAP4K4 | O95819 | 4/20 | 0.40 |
| ▸ | FYN | P06241 | 2/20 | 0.40 |
| ▸ | ABL1 | P00519 | 1/20 | 0.40 |
| ▸ | HPGDS | O60760 | 1/20 | 0.39 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.39 |
| ▸ | SRC | P12931 | 1/20 | 0.39 |
| ▸ | CDC7 | O00311 | 1/20 | 0.39 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.39 |
| ▸ | PIM1 | P11309 | 1/20 | 0.39 |
| ▸ | PRKACA | P17612 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2463664 | 0.83 | CDK9 (0.42) | CDK9CCNT1TAAR1MAP4K4HPGDS | |
| SCHEMBL9929557 | 0.82 | CDK9 (0.56) | CDK9CCNT1MEN1KMT2A | |
| SCHEMBL9930223 | 0.81 | FGFR1 (0.51) | CDK9ALOX5APFEN1MAP4K4FGFR1 | |
| SCHEMBL9929900 | 0.78 | HPGDS (0.50) | CDK9CHEK2MAP4K4FYNHPGDS | |
| SCHEMBL2464140 | 0.77 | CDK9 (0.42) | CDK9CCNT1CHEK2FYNDPP4 | |
| SCHEMBL2459065 | 0.77 | NFE2L2 (0.39) | CDK9CHEK2MAP4K4HPGDSCDC7 | |
| SCHEMBL1462979 | 0.75 | CYP2A6 (0.49) | MEN1 | |
| SCHEMBL21021575 | 0.75 | TAAR1 (0.56) | TAAR1KDM4EMEN1MAPTKMT2A | |
| SCHEMBL1477226 | 0.74 | MAP4K4 (0.70) | TAAR1FEN1CHEK2KDM4EMEN1 | |
| SCHEMBL2552689 | 0.74 | ALOX5AP (0.42) | CDK9TAAR1ALOX5APFEN1CHEK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20120157433-A1 | Heteroaryl Compounds as Kinase Inhibitors | PFISTER KEITH B (US) | 2012-06-21 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120157433-A1 | Heteroaryl Compounds as Kinase Inhibitors | CDK2, CDK1, CDK6 | CDK9 6/4885CCNT1 80/4885TAAR1 4235/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.