Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP2C9 | P11712 | 3/20 | 0.57 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.57 |
| ▸ | BRAF | P15056 | 14/20 | 0.53 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.40 |
| ▸ | MAP2K4 | P45985 | 2/20 | 0.39 |
| ▸ | ALOX5AP | P20292 | 1/20 | 0.38 |
| ▸ | FEN1 | P39748 | 1/20 | 0.38 |
| ▸ | BMPR1B | O00238 | 1/20 | 0.38 |
| ▸ | PLK4 | O00444 | 1/20 | 0.38 |
| ▸ | PIR | O00625 | 1/20 | 0.38 |
| ▸ | AURKA | O14965 | 1/20 | 0.38 |
| ▸ | DCLK1 | O15075 | 1/20 | 0.38 |
| ▸ | EPHB6 | O15197 | 1/20 | 0.38 |
| ▸ | RIPK2 | O43353 | 1/20 | 0.38 |
| ▸ | STK16 | O75716 | 1/20 | 0.38 |
| ▸ | OXSR1 | O95747 | 1/20 | 0.38 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.38 |
| ▸ | ABL1 | P00519 | 1/20 | 0.38 |
| ▸ | RAF1 | P04049 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL914674 | 0.88 | CYP2C9 (0.55) | CYP2C9CYP3A4BRAFMAPTCYP2C19 | |
| SCHEMBL9930639 | 0.87 | CYP2C9 (0.48) | CYP2C9CYP3A4BRAFMAPTALOX5AP | |
| SCHEMBL9931434 | 0.87 | BRAF (0.49) | CYP2C9CYP3A4BRAFMAPTMAP2K4 | |
| SCHEMBL20408709 | 0.86 | CYP2C9 (0.57) | CYP2C9CYP3A4BRAFMAPTCYP2C19 | |
| SCHEMBL9931060 | 0.86 | BRAF (0.49) | CYP2C9CYP3A4BRAFCYP2C19MAP2K4 | |
| SCHEMBL26401647 | 0.85 | CYP2C9 (0.42) | CYP2C9CYP3A4BRAFCYP2C19MAP2K1 | |
| SCHEMBL1492058 | 0.82 | CYP3A4 (0.60) | CYP2C9CYP3A4BRAFCYP2C19MAP2K4 | |
| SCHEMBL1492048 | 0.81 | CYP2C9 (0.48) | CYP2C9CYP3A4BRAFMAPTCYP2C19 | |
| SCHEMBL26401518 | 0.80 | MAP2K4 (0.43) | CYP2C9CYP3A4BRAFMAPTMAP2K4 | |
| SCHEMBL9930589 | 0.78 | BRAF (0.54) | CYP2C9CYP3A4BRAFCYP2C19MAP2K4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20130018033-A1 | RAF INHIBITOR COMPOUNDS AND METHODS OF USE THEREOF | ARRAY BIOPHARMA INC. (US) | 2013-01-17 | — | — | US | claimed |
| US-20130018033-A1 | RAF INHIBITOR COMPOUNDS AND METHODS OF USE THEREOF | ARRAY BIOPHARMA INC. (US) | 2013-01-17 | — | — | US | disclosed |
| US-20120157439-A1 | RAF INHIBITOR COMPOUNDS AND METHODS OF USE THEREOF | GENENTECH, INC. (US) | 2012-06-21 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20130018033-A1 | RAF INHIBITOR COMPOUNDS AND METHODS OF USE THEREOF | BRAF, RAF1, ARAF | CYP2C9 2926/4885CYP3A4 2785/4885BRAF 1/4885 |
| US-20120157439-A1 | RAF INHIBITOR COMPOUNDS AND METHODS OF USE THEREOF | BRAF, RAF1, ARAF | CYP2C9 2926/4885CYP3A4 2785/4885BRAF 1/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.