Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DHODH | Q02127 | 2/20 | 0.49 |
| ▸ | CSNK2A1 | P68400 | 7/20 | 0.47 |
| ▸ | CSNK2A2 | P19784 | 4/20 | 0.47 |
| ▸ | LMNA | P02545 | 3/20 | 0.47 |
| ▸ | CSNK2B | P67870 | 3/20 | 0.47 |
| ▸ | THRB | P10828 | 1/20 | 0.47 |
| ▸ | PTPN5 | P54829 | 1/20 | 0.47 |
| ▸ | CLK1 | P49759 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.46 |
| ▸ | MEN1 | O00255 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.46 |
| ▸ | EGFR | P00533 | 4/20 | 0.45 |
| ▸ | MAP4K4 | O95819 | 2/20 | 0.45 |
| ▸ | PIM1 | P11309 | 2/20 | 0.45 |
| ▸ | MAP4K2 | Q12851 | 2/20 | 0.45 |
| ▸ | DYRK1A | Q13627 | 2/20 | 0.45 |
| ▸ | PIM3 | Q86V86 | 2/20 | 0.45 |
| ▸ | AURKB | Q96GD4 | 2/20 | 0.45 |
| ▸ | CLK4 | Q9HAZ1 | 2/20 | 0.45 |
| ▸ | DYRK3 | O43781 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9930406 | 0.84 | MEN1 (0.44) | DHODHCLK1MEN1KMT2APIM1 | |
| SCHEMBL29116330 | 0.81 | MAPT (0.51) | CSNK2A1LMNACLK1ALDH1A1KMT2A | |
| SCHEMBL9930841 | 0.80 | YTHDC1 (0.35) | CSNK2A1CSNK2A2LMNACSNK2BTHRB | |
| SCHEMBL20200108 | 0.80 | KDM4E (0.50) | ALDH1A1MEN1KMT2AEGFRABCG2 | |
| SCHEMBL9930279 | 0.79 | SYK (0.39) | ALDH1A1MAP4K4PIM1MAP4K2DYRK1A | |
| SCHEMBL2234715 | 0.76 | BRAF (0.47) | CSNK2A1ALDH1A1MEN1KMT2AEGFR | |
| SCHEMBL9930023 | 0.76 | RAF1 (0.34) | CSNK2A1CSNK2A2CSNK2BALDH1A1MAPK1 | |
| SCHEMBL9930605 | 0.76 | SIRT2 (0.45) | ALDH1A1KDM4EAURKARPS6KB1 | |
| SCHEMBL2312296 | 0.75 | MAPT (0.48) | CSNK2A1AURKARPS6KB1 | |
| SCHEMBL9930617 | 0.75 | CSNK2A1 (0.39) | CSNK2A1CSNK2A2LMNACSNK2BALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20120157439-A1 | RAF INHIBITOR COMPOUNDS AND METHODS OF USE THEREOF | GENENTECH, INC. (US) | 2012-06-21 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120157439-A1 | RAF INHIBITOR COMPOUNDS AND METHODS OF USE THEREOF | BRAF, RAF1, ARAF | DHODH 1441/4885CSNK2A1 598/4885CSNK2A2 746/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.