SCHEMBL9930841

SCHEMBL9930841

CNc1ncnc2c(C(=O)O)csc12

nearest known ligand 0.36

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
YTHDC1 Q96MU7 2/20 0.35
YTHDF2 Q9Y5A9 2/20 0.35
MAPT P10636 2/20 0.34
MAPK1 P28482 2/20 0.34
RAF1 P04049 2/20 0.34
CSF1R P07333 2/20 0.34
BRAF P15056 2/20 0.34
DDR1 Q08345 2/20 0.34
DDR2 Q16832 2/20 0.34
ALDH1A1 P00352 2/20 0.33
CSNK2A2 P19784 2/20 0.33
CSNK2B P67870 2/20 0.33
CSNK2A1 P68400 2/20 0.33
TP53 P04637 1/20 0.33
HCAR3 P49019 1/20 0.33
TSHR P16473 1/20 0.33
LPAR1 Q92633 1/20 0.32
LPAR2 Q9HBW0 1/20 0.32
LMNA P02545 2/20 0.32
POLB P06746 1/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL9930605 0.84 SIRT2 (0.45) MAPTBRAFALDH1A1HCAR3LPAR1
SCHEMBL9930023 0.84 RAF1 (0.34) MAPTMAPK1RAF1CSF1RBRAF
SCHEMBL9930221 0.81 HCAR3 (0.40) MAPTRAF1BRAFALDH1A1HCAR3
SCHEMBL9930959 0.81 HCAR3 (0.42) MAPTALDH1A1HCAR3TSHRLPAR1
SCHEMBL9930438 0.80 JAK2 (0.42) MAPTMAPK1RAF1CSF1RBRAF
SCHEMBL9930746 0.80 DHODH (0.49) MAPK1ALDH1A1CSNK2A2CSNK2BCSNK2A1
SCHEMBL9930617 0.80 CSNK2A1 (0.39) MAPTMAPK1ALDH1A1CSNK2A2CSNK2B
SCHEMBL2312296 0.80 MAPT (0.48) MAPTBRAFCSNK2A1HCAR3
SCHEMBL9930640 0.79 PKM (0.38) MAPTMAPK1ALDH1A1TSHRPKM
SCHEMBL9930301 0.79 AURKA (0.35) MAPTRAF1BRAF

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 12 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2014003483-A1 FUSED PYRIMIDINE DERIVATIVES HAVING INHIBITORY ACTIVITY ON FMS KINASES HANMI PHARM. CO., LTD. (KR) 2014-01-03 WO claimed
EP-3617213-B1 THIENO[3,2-D]PYRIMIDINE DERIVATIVES HAVING INHIBITORY ACTIVITY FOR PROTEIN KINASES HANMI PHARMACEUTICAL CO LTD (KR) 2025-02-19 EP disclosed
EP-3617213-A1 THIENO[3,2-D]PYRIMIDINE DERIVATIVES HAVING INHIBITORY ACTIVITY FOR PROTEIN KINASES Hanmi Pharm. Co., Ltd. (KR) 2020-03-04 EP disclosed
EP-2797927-B1 THIENO[3,2-d]PYRIMIDINE DERIVATIVES HAVING INHIBITORY ACTIVITY FOR PROTEIN KINASES HANMI PHARM IND CO LTD (KR) 2019-09-25 EP disclosed
US-RE47451-E1 Thieno[3,2-D]pyrimidine derivatives having inhibitory activity for protein kinases HANMI PHARM. CO. LTD. (KR) 2019-06-25 US disclosed
US-9156852-B2 Thieno[3,2-D]pyrimidine derivatives having inhibitory activity for protein kinases HANMI PHARM. CO., LTD (KR) 2015-10-13 US disclosed
US-20140371219-A1 THIENO[3,2-D]PYRIMIDINE DERIVATIVES HAVING INHIBITORY ACTIVITY FOR PROTEIN KINASES HANMI PHARM. CO., LTD (KR) 2014-12-18 US disclosed
EP-2797927-A1 THIENO[3,2-d]PYRIMIDINE DERIVATIVES HAVING INHIBITORY ACTIVITY FOR PROTEIN KINASES Hanmi Pharm. Co., Ltd. (KR) 2014-11-05 EP disclosed
CN-104039798-A Thieno[3,2-d]pyrimidine derivatives having inhibitory activity for protein kinases HANMI PHARM IND CO LTD 2014-09-10 CN disclosed
WO-2014003483-A1 FUSED PYRIMIDINE DERIVATIVES HAVING INHIBITORY ACTIVITY ON FMS KINASES HANMI PHARM. CO., LTD. (KR) 2014-01-03 WO disclosed
WO-2013100632-A1 THIENO[3,2-d]PYRIMIDINE DERIVATIVES HAVING INHIBITORY ACTIVITY FOR PROTEIN KINASES HANMI PHARM CO., LTD. (KR) 2013-07-04 WO disclosed
US-20120157439-A1 RAF INHIBITOR COMPOUNDS AND METHODS OF USE THEREOF GENENTECH, INC. (US) 2012-06-21 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20140371219-A1 THIENO[3,2-D]PYRIMIDINE DERIVATIVES HAVING INHIBITORY ACTIVITY FOR PROTEIN KINASES TK1, DTYMK, MAP4K2 YTHDC1 3139/4885YTHDF2 2223/4885MAPT 2390/4885
US-20120157439-A1 RAF INHIBITOR COMPOUNDS AND METHODS OF USE THEREOF BRAF, RAF1, ARAF YTHDC1 4656/4885YTHDF2 4501/4885MAPT 1082/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.