Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.59 |
| ▸ | PDE4A | P27815 | 3/20 | 0.46 |
| ▸ | PDE4B | Q07343 | 3/20 | 0.46 |
| ▸ | PDE4C | Q08493 | 3/20 | 0.46 |
| ▸ | PDE4D | Q08499 | 3/20 | 0.46 |
| ▸ | POLB | P06746 | 1/20 | 0.46 |
| ▸ | LMNA | P02545 | 1/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.44 |
| ▸ | TNF | P01375 | 5/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
| ▸ | GAA | P10253 | 1/20 | 0.42 |
| ▸ | RAB9A | P51151 | 1/20 | 0.41 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4626053 | 1.00 | TDP1 (0.59) | TDP1PDE4APDE4BPDE4CPDE4D | |
| SCHEMBL11914467 | 1.00 | TDP1 (0.59) | TDP1PDE4APDE4BPDE4CPDE4D | |
| SCHEMBL5272703 | 0.86 | TDP1 (0.53) | TDP1PDE4APDE4BPDE4CPDE4D | |
| SCHEMBL16648489 | 0.86 | TDP1 (0.57) | TDP1PDE4APDE4BPDE4CPDE4D | |
| SCHEMBL22893524 | 0.85 | TDP1 (0.42) | TDP1PDE4APDE4BPDE4CPDE4D | |
| SCHEMBL16661414 | 0.84 | TDP1 (0.57) | TDP1PDE4APDE4BPDE4CPDE4D | |
| SCHEMBL5274914 | 0.83 | TDP1 (0.53) | TDP1PDE4APDE4BPDE4CPDE4D | |
| SCHEMBL27755640 | 0.82 | TDP1 (0.65) | TDP1PDE4APDE4BPDE4CPDE4D | |
| SCHEMBL9109894 | 0.82 | TDP1 (0.60) | TDP1PDE4APDE4BPDE4CPDE4D | |
| SCHEMBL10639046 | 0.82 | TDP1 (0.51) | TDP1PDE4APDE4BPDE4CPDE4D |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20120157494-A1 | ISOINDOLYL COMPOUNDS | HARRIS III RALPH NEW (US) | 2012-06-21 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120157494-A1 | ISOINDOLYL COMPOUNDS | P2RX7, P2RX3, P2RX1 | TDP1 1089/4885PDE4A 563/4885PDE4B 613/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.