Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 1/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.31 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.31 |
| ▸ | MAPT | P10636 | 1/20 | 0.31 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.31 |
| ▸ | IDO1 | P14902 | 1/20 | 0.30 |
| ▸ | TDO2 | P48775 | 1/20 | 0.30 |
| ▸ | CES2 | O00748 | 1/20 | 0.30 |
| ▸ | CES1 | P23141 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11298970 | 0.79 | CYP3A4 (0.35) | MEN1ALDH1A1CYP3A4MAPTCYP2C9 | |
| SCHEMBL28448111 | 0.73 | IDO1 (0.39) | MEN1ALDH1A1CYP3A4MAPTCYP2C9 | |
| SCHEMBL14232740 | 0.71 | ALDH1A1 (0.40) | MEN1ALDH1A1CYP3A4MAPTCYP2C9 | |
| SCHEMBL11302630 | 0.70 | CYP3A4 (0.38) | MEN1ALDH1A1CYP3A4MAPTCYP2C9 | |
| SCHEMBL9618104 | 0.68 | IDO1 (0.39) | MEN1ALDH1A1CYP3A4MAPTCYP2C9 | |
| SCHEMBL15241658 | 0.68 | EEF2K (0.34) | MEN1CYP3A4KMT2A | |
| SCHEMBL11305491 | 0.65 | CYP3A4 (0.30) | CYP3A4 | |
| SCHEMBL28109023 | 0.65 | CNR2 (0.35) | MEN1ALDH1A1CYP3A4MAPTCYP2C9 | |
| SCHEMBL8089945 | 0.64 | — | — | |
| SCHEMBL9347326 | 0.64 | CES2 (0.42) | MEN1ALDH1A1CYP3A4MAPTCYP2C9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2014015125-A1 | FUSED AMINODIHYDROTHIAZINE DERIVATIVE SALTS AND USES THEREOF | EISAI R&D MANAGEMENT CO., LTD. (JP) | 2014-01-23 | — | — | WO | disclosed |
| EP-2456774-A1 | FUSED AMINODIHYDRO-OXAZINE DERIVATIVES | Eisai R&D Management Co., Ltd. (JP) | 2012-05-30 | — | — | EP | disclosed |
| WO-2011009898-A1 | FUSED AMINODIHYDRO-OXAZINE DERIVATIVES | EISAI R&D MANAGEMENT CO., LTD (JP) | 2011-01-27 | — | — | WO | disclosed |