Nelarabine

Nelarabine

SCHEMBL9937290

COc1nc(N)nc2c1ncn2[C@@H]1O[C@H](CO)[C@H](O)[C@@H]1O

nearest known ligand 0.71

Full drug profile on Sugi Atlas →

Predicted protein targets (top 11)

geneUniProtsupporting neighboursconfidence
CYP2C19 P33261 1/20 0.71
ADORA2A P29274 3/20 0.70
ADORA3 P0DMS8 2/20 0.70
ADORA1 P30542 2/20 0.70
ADORA2B P29275 2/20 0.70
SLC29A1 Q99808 5/20 0.67
PGK1 P00558 1/20 0.64
PGK2 P07205 1/20 0.64
LMNA P02545 1/20 0.61
NT5E P21589 1/20 0.61
HIF1A Q16665 1/20 0.61

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Nelarabine SCHEMBL31326718 1.00 CYP2C19 (0.71) CYP2C19ADORA2AADORA3ADORA1ADORA2B
Nelarabine SCHEMBL1818971 1.00 CYP2C19 (0.71) CYP2C19ADORA2AADORA3ADORA1ADORA2B
Nelarabine SCHEMBL14031852 1.00 CYP2C19 (0.71) CYP2C19ADORA2AADORA3ADORA1ADORA2B
Nelarabine SCHEMBL18820 1.00 CYP2C19 (0.71) CYP2C19ADORA2AADORA3ADORA1ADORA2B
Nelarabine SCHEMBL13575801 1.00 CYP2C19 (0.71) CYP2C19ADORA2AADORA3ADORA1ADORA2B
Nelarabine SCHEMBL2143756 1.00 CYP2C19 (0.71) CYP2C19ADORA2AADORA3ADORA1ADORA2B
Nelarabine SCHEMBL18321891 1.00 CYP2C19 (0.71) CYP2C19ADORA2AADORA3ADORA1ADORA2B
Nelarabine SCHEMBL13657986 1.00 CYP2C19 (0.71) CYP2C19ADORA2AADORA3ADORA1ADORA2B
Nelarabine SCHEMBL20769831 1.00 CYP2C19 (0.71) CYP2C19ADORA2AADORA3ADORA1ADORA2B
Nelarabine SCHEMBL29077509 1.00 CYP2C19 (0.71) CYP2C19ADORA2AADORA3ADORA1ADORA2B

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 176 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-4541381-B1 STABLE, CONCENTRATED RADIONUCLIDE COMPLEX SOLUTIONS ADVANCED ACCELERATOR APPLICATIONS S A (FR) 2026-02-04 EP disclosed
EP-4545101-B1 STABLE, CONCENTRATED RADIONUCLIDE COMPLEX SOLUTIONS ADVANCED ACCELERATOR APPLICATIONS S A (FR) 2025-12-10 EP disclosed
EP-4541380-B1 STABLE, CONCENTRATED RADIONUCLIDE COMPLEX SOLUTIONS ADVANCED ACCELERATOR APPLICATIONS S A (FR) 2025-12-10 EP disclosed
EP-4545100-B1 STABLE, CONCENTRATED RADIONUCLIDE COMPLEX SOLUTIONS ADVANCED ACCELERATOR APPLICATIONS S A (FR) 2025-12-10 EP disclosed
US-12491272-B2 Stable, concentrated radionuclide complex solutions ADVANCED ACCELERATOR APPLICATIONS SA (FR) 2025-12-09 US disclosed
EP-4541379-B1 STABLE, CONCENTRATED RADIONUCLIDE COMPLEX SOLUTIONS ADVANCED ACCELERATOR APPLICATIONS S A (FR) 2025-11-19 EP disclosed
EP-4640241-A2 STABLE, CONCENTRATED RADIONUCLIDE COMPLEX SOLUTIONS Advanced Accelerator Applications S.A. (FR) 2025-10-29 EP disclosed
US-20250295820-A1 Stable, concentrated radionuclide complex solutions ADVANCED ACCELERATOR APPLICATIONS (ITALY) S.R.L. (IT) 2025-09-25 US disclosed
US-12415003-B2 Stable, concentrated radionuclide complex solutions ADVANCED ACCELERATOR APPLICATIONS SA (FR) 2025-09-16 US disclosed
US-20250270555-A1 ORGANIC COMPOSITIONS TO TREAT BETA-CATENIN-RELATED DISEASES ARROWHEAD PHARMACEUTICALS INC (US) 2025-08-28 US disclosed
US-8877801-B2 Compounds and compositions as selective estrogen receptor degraders NOVARTIS AG (CH) 2014-11-04 US disclosed
US-20140235660-A1 COMPOUNDS AND COMPOSITIONS AS SELECTIVE ESTROGEN RECEPTOR DEGRADERS NOVARTIS AG (CH) 2014-08-21 US disclosed
US-20130309247-A1 DIMERIC IAP INHIBITORS NOVARTIS AG (CH) 2013-11-21 US disclosed
EP-2651919-A1 DIMERIC IAP INHIBITORS Novartis AG (CH) 2013-10-23 EP disclosed
EP-2651917-A1 DIMERIC IAP INHIBITORS Novartis AG (CH) 2013-10-23 EP disclosed
US-20130266590-A1 DIMERIC IAP INHIBITORS NOVARTIS AG (CH) 2013-10-10 US disclosed
WO-2013105022-A2 ORGANIC COMPOSITIONS TO TREAT BETA-CATENIN-RELATED DISEASES NOVARTIS AG (CH) 2013-07-18 WO disclosed
US-8445440-B2 Dimeric IAP inhibitors NOVARTIS AG (CH) 2013-05-21 US disclosed
WO-2012080271-A1 DIMERIC IAP INHIBITORS NOVARTIS AG (CH) 2012-06-21 WO disclosed
WO-2012080260-A1 DIMERIC IAP INHIBITORS NOVARTIS AG (CH) 2012-06-21 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (6 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20130309247-A1 DIMERIC IAP INHIBITORS XIAP, BIRC5, BIRC2 CYP2C19 4884/4885ADORA2A 4582/4885ADORA3 4723/4885
US-12415003-B2 Stable, concentrated radionuclide complex solutions EPOR, PAICS, XPO5 CYP2C19 1172/4885ADORA2A 1371/4885ADORA3 1648/4885
US-20130266590-A1 DIMERIC IAP INHIBITORS XIAP, BIRC5, BIRC2 CYP2C19 4884/4885ADORA2A 4653/4885ADORA3 4661/4885
US-12491272-B2 Stable, concentrated radionuclide complex solutions EPOR, PAICS, XPO5 CYP2C19 1172/4885ADORA2A 1371/4885ADORA3 1648/4885
US-20140235660-A1 COMPOUNDS AND COMPOSITIONS AS SELECTIVE ESTROGEN RECEPTOR DEGRADERS ESR1, GPER1, ESR2 CYP2C19 146/4885ADORA2A 528/4885ADORA3 285/4885
US-20250295820-A1 Stable, concentrated radionuclide complex solutions EPOR, PAICS, XPO5 CYP2C19 1172/4885ADORA2A 1371/4885ADORA3 1648/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.