Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PARP1 | P09874 | 1/20 | 0.34 |
| ▸ | RECQL | P46063 | 1/20 | 0.34 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.34 |
| ▸ | HTR2A | P28223 | 1/20 | 0.33 |
| ▸ | GAA | P10253 | 2/20 | 0.33 |
| ▸ | CFB | P00751 | 2/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | RAB9A | P51151 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.33 |
| ▸ | P2RX7 | Q99572 | 2/20 | 0.32 |
| ▸ | REN | P00797 | 1/20 | 0.32 |
| ▸ | SOS2 | Q07890 | 1/20 | 0.32 |
| ▸ | GOT1 | P17174 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.31 |
| ▸ | LMNA | P02545 | 1/20 | 0.31 |
| ▸ | HTT | P42858 | 1/20 | 0.31 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8349453 | 0.92 | PARP1 (0.39) | PARP1RECQLTDP1GAAMEN1 | |
| SCHEMBL6192602 | 0.86 | TDP1 (0.38) | PARP1RECQLTDP1HTR2AGAA | |
| SCHEMBL20350309 | 0.83 | ALDH1A1 (0.36) | PARP1GAACFBMEN1RAB9A | |
| SCHEMBL20756906 | 0.83 | HTR2A (0.39) | HTR2ACFBKMT2AMAPTSMN1; SMN2 | |
| SCHEMBL28126424 | 0.80 | PARP1 (0.41) | PARP1RECQLTDP1GAAMEN1 | |
| SCHEMBL18975746 | 0.78 | P2RX7 (0.34) | PARP1RECQLTDP1P2RX7 | |
| SCHEMBL15629885 | 0.73 | CFB (0.40) | CFBMAPTP2RX7RENALDH1A1 | |
| SCHEMBL18937034 | 0.72 | CYP1A2 (0.36) | CFBMEN1KMT2AKDM4E | |
| SCHEMBL2983820 | 0.71 | ALDH1A1 (0.38) | PARP1RECQLTDP1GAACFB | |
| SCHEMBL30954324 | 0.70 | ALDH1A1 (0.39) | PARP1RAB9AP2RX7ALDH1A1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2651889-A1 | 4-AMINOINDOLE DERIVATIVES AND USE THEREOF FOR THE OXIDATION DYEING OF KERATIN FIBRES | L'Oréal (FR) | 2013-10-23 | — | — | EP | claimed |
| CN-103249718-A | 4-aminoindole derivatives and use thereof for the oxidation dyeing of keratin fibres | OREAL | 2013-08-14 | — | — | CN | claimed |
| WO-2012080288-A1 | 4-AMINOINDOLE DERIVATIVES AND USE THEREOF FOR THE OXIDATION DYEING OF KERATIN FIBRES | L'OREAL (FR) | 2012-06-21 | — | — | WO | claimed |
| EP-2651889-A1 | 4-AMINOINDOLE DERIVATIVES AND USE THEREOF FOR THE OXIDATION DYEING OF KERATIN FIBRES | L'Oréal (FR) | 2013-10-23 | — | — | EP | disclosed |
| CN-103249718-A | 4-aminoindole derivatives and use thereof for the oxidation dyeing of keratin fibres | OREAL | 2013-08-14 | — | — | CN | disclosed |
| WO-2012080288-A1 | 4-AMINOINDOLE DERIVATIVES AND USE THEREOF FOR THE OXIDATION DYEING OF KERATIN FIBRES | L'OREAL (FR) | 2012-06-21 | — | — | WO | disclosed |