Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | MME | P08473 | 3/20 | 0.36 |
| ▸ | ACE | P12821 | 2/20 | 0.36 |
| ▸ | CPA1 | P15085 | 2/20 | 0.36 |
| ▸ | ACE2 | Q9BYF1 | 2/20 | 0.36 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.33 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.33 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.33 |
| ▸ | MMP1 | P03956 | 1/20 | 0.32 |
| ▸ | MMP2 | P08253 | 1/20 | 0.32 |
| ▸ | MMP3 | P08254 | 1/20 | 0.32 |
| ▸ | MEN1 | O00255 | 1/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.31 |
| ▸ | TGFBR1 | P36897 | 2/20 | 0.31 |
| ▸ | TAS1R3 | Q7RTX0 | 1/20 | 0.30 |
| ▸ | TAS1R1 | Q7RTX1 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28709188 | 0.81 | CYP2D6 (0.36) | ALDH1A1MMEACECPA1ACE2 | |
| SCHEMBL6722400 | 0.79 | TAS1R3 (0.42) | ALDH1A1MMEACECPA1ACE2 | |
| SCHEMBL28719760 | 0.77 | CYP2D6 (0.36) | ALDH1A1MMEACECPA1ACE2 | |
| SCHEMBL1437299 | 0.77 | CYP2D6 (0.36) | ALDH1A1MMEACECPA1ACE2 | |
| SCHEMBL12538270 | 0.77 | CYP2D6 (0.36) | ALDH1A1MMEACECPA1ACE2 | |
| SCHEMBL16165794 | 0.77 | CYP2D6 (0.36) | ALDH1A1MMEACECPA1ACE2 | |
| SCHEMBL16165207 | 0.76 | CYP2D6 (0.34) | ALDH1A1MMEACECPA1ACE2 | |
| SCHEMBL1261511 | 0.75 | CNR1 (0.39) | ALDH1A1MMECYP2D6CYP2C19TGFBR1 | |
| SCHEMBL1120240 | 0.75 | CNR1 (0.39) | ALDH1A1MMECYP2D6CYP2C19TGFBR1 | |
| SCHEMBL16648831 | 0.75 | CNR1 (0.39) | ALDH1A1MMECYP2D6CYP2C19TGFBR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2646455-A2 | MODULATORS OF HISTONE METHYLTRANSFERASE, AND METHODS OF USE THEREOF | Epizyme, Inc. (US) | 2013-10-09 | — | — | EP | disclosed |
| WO-2012082436-A2 | MODULATORS OF HISTONE METHYLTRANSFERASE, AND METHODS OF USE THEREOF | Epizyme, Inc. (US) | 2012-06-21 | — | — | WO | disclosed |