Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 1/20 | 0.38 |
| ▸ | MITF | O75030 | 1/20 | 0.38 |
| ▸ | RAB9A | P51151 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.36 |
| ▸ | HPGD | P15428 | 2/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.35 |
| ▸ | GAA | P10253 | 1/20 | 0.35 |
| ▸ | TSHR | P16473 | 2/20 | 0.35 |
| ▸ | MAPT | P10636 | 5/20 | 0.35 |
| ▸ | MEN1 | O00255 | 4/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.35 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.35 |
| ▸ | PABPC1 | P11940 | 1/20 | 0.35 |
| ▸ | BLM | P54132 | 1/20 | 0.35 |
| ▸ | POLB | P06746 | 1/20 | 0.35 |
| ▸ | THRB | P10828 | 1/20 | 0.35 |
| ▸ | S100A4 | P26447 | 1/20 | 0.35 |
| ▸ | BRCA1 | P38398 | 1/20 | 0.35 |
| ▸ | RECQL | P46063 | 1/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3729599 | 0.85 | POLB (0.40) | NPC1MITFRAB9AKMT2AALDH1A1 | |
| SCHEMBL5668159 | 0.83 | MEN1 (0.37) | NPC1MITFRAB9AKMT2AALDH1A1 | |
| SCHEMBL10760096 | 0.78 | NPC1 (0.36) | NPC1MITFRAB9AKMT2AALDH1A1 | |
| SCHEMBL2734403 | 0.75 | NPC1 (0.37) | NPC1MITFRAB9AKMT2AHPGD | |
| SCHEMBL3373922 | 0.75 | MEN1 (0.35) | NPC1MITFRAB9AKMT2AALDH1A1 | |
| SCHEMBL3266678 | 0.75 | MEN1 (0.41) | NPC1MITFRAB9AKMT2AHPGD | |
| SCHEMBL3714616 | 0.74 | ALDH1A1 (0.39) | NPC1MITFRAB9AKMT2AHPGD | |
| SCHEMBL6053048 | 0.73 | ACKR3 (0.35) | NPC1RAB9AKMT2AALDH1A1GAA | |
| Bromide SCHEMBL1169843 | 0.73 | POLB (0.33) | NPC1MITFRAB9AKMT2AHPGD | |
| SCHEMBL8448450 | 0.73 | HTR2A (0.40) | KMT2AALDH1A1MAPTMEN1KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2651403-A2 | USE OF LP-PLA2 INHIBITORS IN THE TREATMENT AND PREVENTION OF EYE DISEASES | Glaxo Group Limited (GB) | 2013-10-23 | — | — | EP | claimed |
| WO-2012080497-A2 | METHODS OF TREATMENT AND PREVENTION OF EYE DISEASES | GLAXO GROUP LIMITED (GB) | 2012-06-21 | — | — | WO | claimed |
| EP-0233800-B1 | Imidazo[1,2-a]quinoline derivatives, their preparation and therapeutical use thereof | SYNTHELABO (FR) | 1990-02-28 | — | — | EP | disclosed |
| EP-0233800-A1 | Imidazo[1,2-a]quinoline derivatives, their preparation and therapeutical use thereof | SYNTHELABO (FR) | 1987-08-26 | — | — | EP | disclosed |