Cadaverine Tartrate

Cadaverine Tartrate

SCHEMBL9938548

CC(=O)NCc1ccc(-c2ccc(C)cc2)cc1.O=C(O)C(O)C(O)C(=O)O

nearest known ligand 0.55

Full drug profile on Sugi Atlas →

Known targets — ChEMBL curated mechanism

ADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ADRB3CHRM1CHRM2CHRM3CHRM4ESR1ESR2GABRA1GABRB1GABRG2GBA1HRH1HTR1DHTR2AOPRD1OPRK1OPRM1SLC6A2SLC6A3TUBA1ATUBA1BTUBA1CTUBA3CTUBA3ETUBA4ATUBBTUBB1TUBB2ATUBB2BTUBB3TUBB4ATUBB4BTUBB6TUBB8rplArplBrplCrplDrplErplFrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmFrpmGrpmHrpmIrpmJrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUykgMykgO

The experimentally established mechanism targets of Cadaverine Tartrate. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
KMT2A Q03164 6/20 0.55
MEN1 O00255 5/20 0.55
ADAMTS4 O75173 1/20 0.52
MMP13 P45452 1/20 0.52
SMN1; SMN2 Q16637 2/20 0.51
VHL P40337 1/20 0.48
ALDH1A1 P00352 3/20 0.48
TDP1 Q9NUW8 1/20 0.48
LMNA P02545 1/20 0.48
HDAC1 Q13547 3/20 0.47
HDAC3 O15379 2/20 0.47
HDAC2 Q92769 2/20 0.47
HDAC8 Q9BY41 2/20 0.47
HDAC4 P56524 1/20 0.47
HDAC11 Q96DB2 1/20 0.47
NPC1 O15118 4/20 0.47
RAB9A P51151 4/20 0.47
TP53 P04637 1/20 0.47
HPGD P15428 1/20 0.47
HDAC6 Q9UBN7 1/20 0.46

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Cadaverine Tartrate SCHEMBL9938634 0.88 KMT2A (0.53) KMT2AMEN1ADAMTS4MMP13SMN1; SMN2
Cadaverine Tartrate SCHEMBL9937385 0.88 KMT2A (0.53) KMT2AMEN1ADAMTS4MMP13SMN1; SMN2
Cadaverine Tartrate SCHEMBL3633165 0.86 ADAMTS4 (0.48) KMT2AMEN1ADAMTS4MMP13SMN1; SMN2
Cadaverine Tartrate SCHEMBL9936743 0.85 ADAMTS4 (0.53) KMT2AMEN1ADAMTS4MMP13SMN1; SMN2
SCHEMBL171709 0.83 KMT2A (0.66) KMT2AMEN1SMN1; SMN2ALDH1A1LMNA
Cadaverine Tartrate SCHEMBL3634786 0.83 PPARA (0.51) KMT2AADAMTS4MMP13HDAC1HDAC3
SCHEMBL5801663 0.79 KMT2A (0.65) KMT2AMEN1ADAMTS4MMP13SMN1; SMN2
SCHEMBL12133623 0.76 KMT2A (0.76) KMT2AMEN1SMN1; SMN2VHLALDH1A1
Toluene SCHEMBL29122543 0.75 SMN1; SMN2 (0.68) KMT2AMEN1SMN1; SMN2ALDH1A1HDAC1
SCHEMBL5437522 0.75 KDM4E (0.59) KMT2AADAMTS4MMP13SMN1; SMN2VHL

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2651403-A2 USE OF LP-PLA2 INHIBITORS IN THE TREATMENT AND PREVENTION OF EYE DISEASES Glaxo Group Limited (GB) 2013-10-23 EP disclosed
WO-2012080497-A2 METHODS OF TREATMENT AND PREVENTION OF EYE DISEASES GLAXO GROUP LIMITED (GB) 2012-06-21 WO disclosed